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Levitra Tablets (vardenafil) 

Indications 

Levitra is used to treat erectile dysfunction, which is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. 

Dosage and Administration

• Take Levitra exactly as prescribed by your doctor. 
• Take the tablet orally with or without food, about 60 minutes before sexual activity. 
• Swallow the tablet whole with a full glass of water. 
• Only take Levitra once per day, as needed. 
• Do not take more than one dose per day. 
• Avoid consuming grapefruit or grapefruit juice while taking Levitra, as it can interfere with the medication’s effectiveness. 
• Do not use Levitra in combination with other treatments for erectile dysfunction unless advised by your doctor. 
• Avoid heavy or fatty meals close to the time you take Levitra, as they can slow down its absorption and effectiveness. 

Mechanism of Action 

Levitra is a phosphodiesterase type 5 (PDE5) inhibitor. It works by increasing blood flow to the penis during sexual stimulation. Vardenafil achieves this by inhibiting the enzyme PDE5, which regulates blood flow in the penis. By blocking this enzyme, Levitra helps maintain an erection by enhancing the natural erectile response to sexual stimulation. 

Contraindications 

• Allergy to Vardenafil: Do not use it if you have had an allergic reaction to Vardenafil or any other ingredients in Levitra. 
• Nitrate Medications: Avoid using Levitra if you are taking nitrates for chest pain or heart problems, as this can cause a severe drop in blood pressure. 
• Severe Heart or Liver Problems: Not recommended for patients with severe cardiovascular or liver conditions. 
• Recent Stroke or Heart Attack: Avoid use if you have had a stroke or heart attack within the past 6 months. 
• Low Blood Pressure: Not suitable for patients with hypotension (low blood pressure). 
• Retinitis Pigmentosa: Avoid use if you have this rare inherited eye condition. 

Side Effects 

Common Side Effects 

• Headache 
• Flushing 
• Stuffy or runny nose 
• Indigestion 
• Dizziness 

Serious Side Effects 

• Sudden vision loss in one or both eyes 
• Sudden hearing loss or ringing in the ears 
• Chest pain or heavy feeling, pain spreading to the arm or shoulder 
• Irregular heartbeat 
• Shortness of breath 
• Seizures 

Precautions 

• Cardiovascular Health: Inform your doctor of any history of heart problems, as sexual activity may strain your heart. 
• Priapism: Seek immediate medical attention if you experience an erection lasting longer than 4 hours. 
• Vision and Hearing: Stop using Levitra and seek medical help if you experience sudden vision or hearing loss. 
• Drug Interactions: Discuss all medications you are taking with your doctor to avoid potential interactions, especially with alpha-blockers, antihypertensives, and other PDE5 inhibitors. 
• Alcohol Use: Limit alcohol intake, as it can increase certain side effects of Levitra. 

Storage Instructions 

• Store Levitra tablets at room temperature between 20°C to 25°C (68°F to 77°F). 
• Keep the tablets in their original container to protect them from light and moisture. 
• Keep out of reach of children. 
• Do not use the tablets after the expiration date on the label. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021400s017lbl.pdf