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Jardiance (empagliflozin) 

Indications

• Jardiance is prescribed for various conditions, like: 
• Reduction of the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure. 
• Reduction of the risk of cardiovascular death in adults diagnosed with type 2 diabetes mellitus and established cardiovascular disease. 
• Improvement of glycemic control in adults with type 2 diabetes mellitus as a complement to diet and exercise. 

Ingredients

Active ingredient: empagliflozin

Inactive ingredients: lactose monohydrate, microcrystalline cellulose, hyprolose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate.

Dosage and Administration

• Read the Medication Guide provided by your pharmacist before starting Jardiance. 
• Take this medication orally with or without food as directed by your healthcare provider, usually once daily in the morning. 
• Use Jardiance regularly to maximize its benefits. 
• Inform your healthcare provider if your condition does not improve or worsens. 
• Do not alter the dosage without consulting your healthcare provider. 
• Do not discontinue the medication without consulting your healthcare provider. 
• Do not share this medication with others even if they have similar symptoms. 

Mechanism of Action

Jardiance works by blocking a specific protein in the kidneys, which helps the body eliminate glucose through urine. This action leads to a decrease in blood sugar levels. 

Contraindications

Jardiance is contraindicated in: 

• Individuals with hypersensitivity to empagliflozin or any of its components. 
• Patients undergoing dialysis. 

Side Effects

Common Side Effects: 

• Bladder pain 

• Cloudy or bloody urine 

• Change in vaginal discharge (color, amount, odor) 

• Painful or burning urination 

• Frequent urge to urinate 

• Itching, stinging, or redness of the vaginal area 

• Lower back or side pain 

• Pain during sexual intercourse 

• Mild urinary tract infection (UTI) 

• Mild genital yeast infection 

• Increased frequency of urination 

• Elevated levels of fats or cholesterol in the blood 

• Joint pain 

• Nausea 

• Kidney problems 

Less Common Side Effects: 

• Discharge with a strong odor from the penis 

Serious Side Effects: 

• Dehydration (manifested by dizziness or lightheadedness) 

• Low blood pressure 

• Hypoglycemia (low blood sugar) 

• Ketoacidosis (excess acid in the blood) 

• Acute kidney impairment or injury 

• Allergic reactions 

Precautions

Ketoacidosis: Watch out for symptoms such as nausea, vomiting, abdominal pain, and difficulty breathing. 

Volume Depletion: Be cautious if you are prone to dehydration or taking medications that can lead to fluid loss. 

Urosepsis and Pyelonephritis: Inform your healthcare provider if you experience symptoms like fever, chills, or lower back pain. 

Hypoglycemia: Monitor your blood sugar levels regularly, especially if you are on other medications that can lower blood sugar. 

Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene): Seek medical attention immediately if you experience severe pain, swelling, or redness in the genital or perineal area. 

Genital Mycotic Infections: Keep the genital area clean and dry and report any unusual symptoms to your healthcare provider promptly. 

Hypersensitivity Reactions: Stop taking Jardiance and seek medical help if you develop signs of a serious allergic reaction, such as rash, itching, swelling, or difficulty breathing. 

Storage Instructions

• Store Jardiance at room temperature between 20°C to 25°C (68°F to 77°F). Excursions permitted from 15°C to 30°C (59°F to 86°F). 
• Keep away from excessive heat and moisture. 
• Keep out of reach of children and pets. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/204629s033lbl.pdf