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Corlanor (ivabradine) 

Indications 

Corlanor is a medicine that helps: 

• Lower the chance of going to the hospital for adults with chronic heart failure whose hearts pump blood less effectively. 
• Treat stable heart failure in children over 6 months old with dilated cardiomyopathy, where the heart becomes enlarged and weak. 

Dosage and Administration 

• Take Corlanor exactly as prescribed by your healthcare provider. 
• Take Corlanor at the same time each day, with or without food. 
• Take Corlanor regularly to get the most benefit from it. 
• Do not crush, chew, or break the tablets before swallowing.   
• Do not double the dose to catch up. 
• Do not stop taking Corlanor suddenly without consulting your doctor, as it may worsen your condition. 
• Avoid alcohol while taking Corlanor, as it may increase the risk of side effects such as dizziness or fainting. 
• Avoid driving or operating heavy machinery until you know how Corlanor affects you as it might cause dizziness. 

Mechanism of Action  

Corlanor works by slowing down the heart rate. It does this by blocking certain channels in the heart. Slowing the heart rate helps the heart work better and lowers the chance of needing to go to the hospital for heart problems. 

Contraindications  

Corlanor should not be used if you have: 

• Acute decompensated heart failure 
• Clinically significant hypotension 
• Sick sinus syndrome, sinoatrial block, or third-degree AV block, unless a functioning demand pacemaker is present 
• Clinically significant bradycardia 
• Severe hepatic impairment 
• Heart rate maintained exclusively by the pacemaker 
• In combination with strong cytochrome CYP3A4 inhibitors 

Side Effects  

Common Side Effects 

• Bradycardia (slow heart rate) 
• High blood pressure 
• Dizziness 
• Headache 
• Temporary visual brightness or light disturbances 

Serious Side Effects 

• Atrial fibrillation 
• Heart rhythm problems 
• Fainting or feeling faint 
• Shortness of breath or difficulty breathing 

Precautions 

• Fetal Toxicity: If you are a woman of childbearing age, you should use effective contraception while taking Corlanor.
• Atrial Fibrillation Monitoring: Regularly monitor patients for signs of atrial fibrillation.
• Heart Rate Monitoring: Monitor for decreases in heart rate and symptoms of bradycardia during treatment.
• Second-Degree AV Block: Corlanor is not recommended if you have a second-degree AV block.

Storage Instructions 

• Store Corlanor tablets at room temperature, around 25°C (77°F). 
• Keep Corlanor in its original packaging to protect it from light and moisture. 
• Keep out of reach of children and pets. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209964lbl.pdf