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Januvia (sitagliptin) 

Januvia is a brand-name medication that requires a doctor’s prescription. Its generic name is Sitagliptin. Januvia is used together with proper exercise and a healthy diet to reduce blood sugar levels in adult patients with type 2 diabetes mellitus. Januvia drug is not recommended to treat patients who have type 1 diabetes mellitus.

Ingredients

Active ingredient: sitagliptin phosphate monohydrate

Inactive ingredient: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and yellow iron oxide

Dosage and Administration 

• Take Januvia by mouth with or without food, as directed by your healthcare provider, usually once daily. 
• Take Januvia at the same time each day to maintain consistency. 
• Follow the medication treatment plan, meal plan, and exercise program recommended by your healthcare provider. 
• Do not adjust the dosage without consulting your healthcare provider. 
• Do not discontinue Januvia without consulting your healthcare provider. 
• Do not take more or less medication than prescribed. 

Contraindications

History of a serious hypersensitivity reaction to sitagliptin, such as anaphylaxis or angioedema.

Side Effects

Common Side Effects: 

• Upper respiratory infection 
• Stuffy or runny nose 
• Sore throat 
• Headache 
• Stomach upset 
• Diarrhea 

Serious Side Effects: 

• Signs of heart failure 
• Unusual skin blisters 
• Joint pain 
• Signs of pancreatitis such as severe stomach or abdominal pain, nausea, vomiting, and loss of appetite 

Long-Term Side Effects: 

• Heart failure 
• Abnormal heart rhythms 
• Blood clots 
• Stroke

Precautions

• There have been postmarketing reports of acute pancreatitis and acute renal failure with Januvia. Promptly discontinue Januvia if pancreatitis is suspected. Assess renal function before initiating Januvia and periodically thereafter. 
• Increased risk of hypoglycemia when Januvia is added to insulin secretagogues or insulin therapy. Consider lowering the dose of sulfonylurea or insulin to reduce the risk of hypoglycemia. 
• Serious allergic and hypersensitivity reactions, such as anaphylaxis and angioedema, have been reported. Discontinue Januvia promptly if such reactions occur. 
• No clinical studies have established conclusive evidence of macrovascular risk reduction with Januvia or any other anti-diabetic drug.

Storage Instructions

• Store Januvia at 20-25°C (68-77°F), excursions permitted to 15-30°C (59-86°F). 
• Keep Januvia in its original container, tightly closed, and out of reach of children.