Are you Looking to Buy Imuran (Azathioprine) from PrescriptionPoint.

Imuran (azathioprine) 

Indications 

• Prevention of Organ Rejection 
• Used in combination with other medications to prevent rejection of transplanted organs, such as kidneys, by suppressing the immune response. 
• Autoimmune Diseases 
• Treats various autoimmune diseases, including rheumatoid arthritis, lupus, and inflammatory bowel disease (Crohn’s disease and ulcerative colitis), by reducing immune system activity. 
• Severe Cases of Eczema 
• Prescribed for severe cases of eczema that do not respond to other treatments, helping to reduce inflammation and immune response. 

Dosage and Administration 

• Take Imuran exactly as prescribed by your healthcare provider. 
• Take the medication at the same time each day to maintain consistent levels in your bloodstream. 
• Take it with or without food, although taking it with food may help reduce stomach upset. 
• Undergo regular blood tests as advised by your doctor to monitor blood cell counts and liver function. 
• Do not crush, chew, or break the tablet; swallow it whole. 
• Do not miss doses. If you forget a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose. 
• Do not consume grapefruit or grapefruit juice while taking Imuran, as it can interact with the medication. 
• Avoid close contact with people who have infections, as Imuran can weaken your immune system. 

Mechanism of Action 

Imuran (azathioprine) works by inhibiting the synthesis of DNA in rapidly dividing cells, particularly immune cells. This suppresses the immune response, helping to prevent organ rejection and reduce the activity of the immune system in autoimmune diseases. It achieves this by interfering with the production of purines, which are essential components of DNA. 

Contraindications 

• Allergic Reactions: Do not use if you are allergic to azathioprine or any of its components. 
• Pregnancy: Not recommended for use during pregnancy unless clearly needed, due to potential harm to the unborn baby. 
• Severe Liver Disease: Avoid use if you have severe liver impairment. 
• Previous Cancer: Patients with a history of cancer should avoid use unless clearly necessary, as azathioprine can increase the risk of developing malignancies. 
• Thiopurine Methyltransferase (TPMT) Deficiency: Not suitable for individuals with TPMT deficiency, a genetic condition that affects the body’s ability to break down the medication. 

Side Effects 

Common Side Effects: 

• Nausea 
• Vomiting 
• Diarrhea 
• Loss of appetite 
• Rash 
• Fatigue 

Serious Side Effects: 

• Unusual bruising or bleeding 
• Severe stomach pain 
• Signs of infection (fever, chills, sore throat) 
• Jaundice (yellowing of the skin or eyes) 
• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing) 
• Signs of liver problems (dark urine, persistent nausea/vomiting) 

Precautions 

• Regular Monitoring: Undergo regular blood tests to monitor blood cell counts and liver function. 
• Inform About Other Medications: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements, to avoid interactions. 
• Sun Exposure: Limit sun exposure and use sunscreen or protective clothing, as Imuran can increase the risk of skin cancer. 
• Vaccinations: Avoid live vaccines while taking Imuran, as they may not work as well or could cause infections. 
• Report Symptoms of Infection: Immediately report any signs of infection to your doctor, such as fever, chills, or sore throat. 
• Regular Cancer Screenings: Regularly undergo cancer screenings as recommended by your healthcare provider, due to the increased risk of malignancies. 

Storage Instructions 

• Store at room temperature between 20°C to 25°C (68°F to 77°F). 
• Keep in a dry place away from moisture and direct sunlight. 
• Store the tablets in their original packaging until it’s time to take them. 
• Keep out of the reach of children and pets. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/016324s039lbl.pdf