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What is Effexor XR?

Effexor XR is the brand name of venlafaxine, which is a serotonin and norepinephrine reuptake inhibitor (SSRI). Effexor XR is used to treat adults who have mental health conditions such as major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder.

Effexor XR works by blocking the reuptake of two neurotransmitters called serotonin and norepinephrine that transmit nerve signals and are involved in regulating mood.

Effexor XR dosage

Effexor XR comes in an extended-release capsule and is available in three different strengths, 37.5 mg, 75 mg, and 150 mg.

The following are the recommended Effexor XR dosages for each condition: 

For the treatment of Major Depressive Disorder in adults, the initial dose is 75 mg once per day. A maintenance dose is 75 to 225 mg once per day. The maximum dose for moderately depressed outpatients is 225 mg per day.

-For patients who need time to adjust to the medication, it is desirable to give an initial dose of 37.5 mg per day for 4 to 7 days before increasing to 75 mg a day. Doses may be raised in daily increments of up to 75 mg at intervals of not less than 4 days.

For the treatment of Generalized Anxiety Disorder in adults, the initial dose is 75 mg once per day. The maintenance dose is 75 to 225 mg once per day. The maximum dose should not be more than 225 mg a day.

For the treatment of Social Anxiety Disorder in adults, the initial dose is 75 mg once a day. There is no proof that doses higher than 75 mg per day confer further benefit. 

For the treatment of panic disorder in adults, the initial dose is 37.5 mg once a day for 1 week. Patients who do not respond to 75 mg a day may benefit from dose increases to a maximum of approximately 225 mg a day. Dose increases should be in increments of up to 75 mg a day, as needed, and at intervals of not less than 7 days (one week).


Take Effexor XR precisely as prescribed by your physician. Read all the medication guides and instruction sheets and follow carefully all the instructions on the prescription label.

You should take Effexor XR orally at the same time each day on a full stomach or with food.

Swallow the extended-release capsule whole with fluid and do not chew, crush, divide or break it. For easier swallowing, you may open the capsule carefully and sprinkle the whole contents on a spoonful of applesauce.


Do not take Effexor XR if you are allergic to it or to any of its active and inactive components.

Do not take Effexor XR if you presently take or have taken within the last 2 weeks (14 days) an MAO inhibitor such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

Effexor XR should not be given to those who are below 18 years old because it has not been approved for use in pediatric patients.

Before taking Effexor XR, inform your doctor about all medications you take, including non-prescription and prescription drugs, vitamins, supplements, and especially herbal products, opioid medicines, stimulant medications, medicine for depression, mental illness, migraine headaches, Parkinson’s disease, serious infections, or prevention of nausea and vomiting.

These medications’ interaction with Effexor XR could lead to a serious condition known as serotonin syndrome.

To ensure your safety, tell your doctor before you use this medicine if you have or have had the following: 

Liver or kidney disease 

Bipolar disorder or mania 

Elevated blood pressure, high cholesterol, and other heart diseases 


Glaucoma (closed-angle glaucoma) 

Seizures or convulsions 

Low sodium levels in the blood 

Bleeding problems 

Thyroid disorder 

Sexual problems

Patients taking antidepressants should be monitored closely for signs of becoming suicidal or their condition becoming worse, especially during their initial use of the medication or when the dose is decreased or increased. Also, family members and other caregivers should be alert to any changes in the patient’s mood or symptoms.

Effexor XR side effects 

Headache, dizziness 

Drowsiness or Insomnia 


Dry mouth 

Loss of appetite 

Nausea, diarrhea

-Increased sweating 

Restless, Feeling nervous

-Sexual problems

-Weight loss or weight gain

Here are some rare but serious side effects of Effexor XR: 

Elevated blood pressure 

Bruising or bleeding more easily than usual (nosebleeds, coughing up blood, blood in the stool, black tarry stool, and vomit that looks like coffee grounds) 

Low sodium levels in the blood (Hyponatremia) are shown by weakness, headache, trouble focusing, fainting, and seizure. 

Seizure (convulsions) 

Serotonin syndrome is shown by fever, agitation, sweating, shivering, rapid heart rate, twitching, loss of coordination, seizure, nausea, vomiting, and diarrhea. 

A serious allergic reaction is shown by rash, itching, swelling of the face, lips, tongue, or throat, and trouble breathing. 

If any of the conditions and symptoms listed above occur, contact your doctor at once or seek medical help right away.

Effexor XR weight gain

Weight changes are common in depression and anxiety, which this medication treats. So, patients may lose or gain weight while taking Effexor XR because their condition is becoming better. This means that weight changes may not be a side effect of this medication itself.

How much is the Effexor XR price in Canada? 

Effexor XR cost will depend on the dose you need. Check the top of the page to see how affordable our prices are for this drug.

Frequently asked questions about Effexor XR

What could happen if Effexor XR and alcohol are taken together? 

Each of them can cause sleepiness or drowsiness and trouble concentrating. Therefore, when you take them together, these side effects could get worse, which is dangerous.

What are Effexor XR withdrawal symptoms? 

Stopping Effexor XR suddenly can lead to withdrawal symptoms such as confusion, dizziness, headache, anxiety, agitation, insomnia, flu-like symptoms, dry mouth, shakiness, lack of coordination, diarrhea, nausea, and vomiting.

Is it better to take Effexor XR in the morning or at night? 

-It’s fine to take them at any time as long as you take them at the same time every day. Taking it in the morning is the best option if you have trouble sleeping.

Can I take ibuprofen while on Effexor XR? 

It is possible to experience bleeding when taking venlafaxine with ibuprofen. Elderly people or those with kidney or liver disease are more likely to experience this interaction. 

Additional information

Brand Name:

Effexor XR

Scientific Name:

Venlafaxine XR, Venlafaxine Xr

Other Names:

Efexor XR, Effexor XR, Venlafaxine XL, Venlor XR


37.5mg, 75mg, 150mg

Quantities Available:

28, 84, 100


Capsule, ER Capsule

The information above is provided by third parties to for Effexor XR (Venlafaxine Xr). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.