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Advair Diskus (fluticasone propionate and salmeterol)

Indications

• Long-term treatment for the control and prevention of asthma symptoms in adults and children aged 4 years and older.
• Maintenance treatment for airflow obstruction and reducing exacerbations in patients with COPD, including chronic bronchitis and emphysema.

Dosage and Administration

• Use the Diskus device exactly as prescribed by your doctor, typically one inhalation twice daily.
• Inhale the medication through your mouth using the Diskus device, making sure to exhale fully before use.
• Rinse your mouth with water without swallowing after each use to help prevent oral thrush.
• Do not use the Diskus more than twice daily.
• Avoid using it to treat sudden asthma attacks; use a rescue inhaler for acute symptoms.
• Do not discontinue use abruptly without consulting your doctor, even if you feel better.

Mechanism of Action

Advair Diskus contains two active ingredients: fluticasone propionate, a corticosteroid, and salmeterol, a long-acting beta2-adrenergic agonist (LABA). Fluticasone propionate works by reducing inflammation and swelling in the airways, while salmeterol helps to relax the muscles around the airways, making it easier to breathe. Together, they help control and prevent asthma and COPD symptoms.

Contraindications

• Allergic Reaction: Do not use if you are allergic to fluticasone, salmeterol, or any other ingredients in Advair Diskus.
• Primary Treatment of Acute Asthma: Avoid using Advair Diskus as the primary treatment for acute asthma symptoms.
• Severe Hypersensitivity to Milk Proteins: Do not use the Advair Diskus if you have a severe allergy to milk proteins.

Side Effects

Common Side Effects:

• Headache
• Throat irritation
• Hoarseness
• Cough
• Upper respiratory tract infections

Serious Side Effects:

• Worsening asthma symptoms
• Chest pain or palpitations
• High blood pressure
• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing)
• Increased risk of pneumonia in COPD patients
• Osteoporosis (bone density loss) with long-term use

Precautions

• Asthma Attacks: Keep a rescue inhaler on hand for sudden asthma symptoms.
• Regular Monitoring: Monitor lung function regularly as advised by your doctor.
• Infection Risk: Be aware of an increased risk of infections due to the immunosuppressive effects of corticosteroids.
• Bone Health: Discuss the risk of bone density loss with long-term use, especially in postmenopausal women.
• Diabetes: Monitor blood sugar levels if you have diabetes, as corticosteroids can affect glucose control.
• Eye Health: Regular eye exams are recommended, as corticosteroids can increase the risk of cataracts and glaucoma.

Storage Instructions

• Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep away from excessive moisture; do not store Advair Diskus in the bathroom.
• Protect from light and heat to maintain efficacy.
• Keep out of reach of children to prevent accidental use.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021077s042lbl.pdf