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Asacol (mesalamine) 

Indications 

• Asacol is used to treat mild to moderate ulcerative colitis, an inflammatory bowel disease. 
• It helps to induce and maintain remission of ulcerative colitis, reducing symptoms such as diarrhea, rectal bleeding, and stomach pain. 
• Asacol is effective for both acute flare-ups and long-term maintenance therapy. 

Dosage and Administration 

• Take Asacol exactly as prescribed by your doctor, usually 2-4 times daily. 
• Swallow the tablets whole with a full glass of water, with or without food. 
• Take your doses at evenly spaced intervals throughout the day to maintain consistent levels of medication in your body. 
• Inform your doctor about all other medications you are taking to avoid potential interactions. 
• Follow your doctor’s instructions regarding regular monitoring of your condition and response to treatment. 
• Do not crush, chew, or break the tablets. 
• Avoid taking more than the prescribed dose without consulting your doctor. 
• Do not stop taking Asacol suddenly without your doctor’s approval. 

Mechanism of Action 

Asacol contains Mesalamine, an anti-inflammatory agent. It works by reducing inflammation in the lining of the colon, thereby alleviating symptoms of ulcerative colitis. Mesalamine inhibits the production of inflammatory mediators and promotes tissue healing, helping to induce and maintain remission of the disease. 

Contraindications 

• Do not use Asacol if you are allergic to mesalamine or any of its ingredients. 
• Avoid using Asacol if you have severe kidney disease or a history of allergic reactions to sulfasalazine or its derivatives. 
• Do not take it if you have severe liver disease without consulting your doctor. 

Side Effects 

Common Side Effects: 

• Headache 
• Nausea 
• Diarrhea 
• Stomach pain 
• Gas 

Serious Side Effects: 

• Severe allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing 
• Severe stomach pain or cramping 
• Bloody diarrhea 
• Signs of kidney problems, such as changes in urine output or swelling of the feet or ankles 
• Signs of liver problems, such as yellowing of the skin or eyes, dark urine 

Precautions 

• Inform your doctor about all other medications you are using, including over-the-counter products and supplements. 
• Use caution if you are pregnant, planning to become pregnant, or breastfeeding, and discuss the risks and benefits with your doctor. 
• Stay hydrated, especially if you experience diarrhea while taking Asacol. 
• Monitor your condition regularly and report any worsening symptoms to your doctor. 
• If you experience severe side effects or signs of an allergic reaction, seek medical attention immediately. 

Storage Instructions 

• Store Asacol at room temperature, between 20°C to 25°C (68°F to 77°F). 
• Keep the tablets in their original container, tightly closed. 
• Store Asacol out of reach of children and pets. 
• Protect the tablets from moisture and light. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019651s023lbl.pdf