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Dosage: 400mg
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Dosage: 400mg
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What is Asacol?

Asacol (Mesalamine) is a brand name prescription medication used to treat inflammatory bowel diseases (IBD) such as Ulcerative Colitis and Crohn’s disease.

This medication relieves the symptoms of mild-to-moderate ulcerative colitis such as stomach pain, cramping, diarrhea, and rectal bleeding, and prevents further episodes of this condition.

Mesalamine can also be used to treat and prevent relapse of mild-to-moderate Crohn’s disease.

How does Asacol work?

Asacol contains the active ingredient mesalamine, which is an aminosalicylate, belonging to the class of drugs known as anti-inflammatory.

Prostaglandins and leukotrienes are chemicals that cause inflammation. This medication inhibits the production of these two chemicals by blocking the actions of cyclooxygenase, which produces prostaglandins, and lipoxygenase, which produces leukotrienes. This action results in reducing inflammation in the colon and rectum.

This prescription drug also acts as an antioxidant and prevents the movement of macrophages (inflammatory cells) into the intestinal wall, protecting the walls of the intestine from cell damage.

Asacol dosage and how to take it

Take mesalamine exactly as prescribed by your healthcare provider.

Asacol comes in tablet form, available in the strength of 400 mg.

For the treatment of ulcerative colitis, the recommended dose is 2400mg to 4800mg per day in individual doses.

For the prevention of an episode of ulcerative colitis, it is recommended to take 1200mg to 2400mg per day, once daily or in divided doses.

For the prevention of an episode of Crohn’s, it is recommended to take 2400mg per day in divided doses.

The most suitable dosage for you will be determined by your doctor. You should not change the prescribed dose by yourself.

Take mesalamine with a glass of water and swallow it whole, with or without food, but preferably before your meal. Be sure not to crush, chew, or break this medication.

Asacol effectiveness

Asacol effectively treats inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease and prevents the symptoms of the said conditions from recurring. It contains an active ingredient called mesalamine, which is an anti-inflammatory medication.

An improvement can be usually observed in 3 to 21 days. About 6 weeks of treatment may be needed to get good results.

Asacol side effects

The most common side effects when using Asacol 400 mg are nausea and/or vomiting, diarrhea, stomach/epigastric pain, flatulence, headache, muscle or joint pain, indigestion, and fever.

The serious side effects of taking Asacol 400 mg are as follows: 

-Allergic reaction is shown by itching, rash, swelling of the face, lips, tongue, or throat, and trouble breathing. 

-Fever and sore throat 

-Lip or mouth ulcers. 

-Spots underneath the skin (anywhere on the body) 

-Pale skin 

-Swollen ankles 

-Unusual bleeding such as bleeding gums or sudden nosebleeds 

-Change in the urine’s color or amount

Asacol kidney damage

In patients taking this drug or products converted to mesalamine, renal impairment (including minimal change in nephropathy), acute and chronic interstitial nephritis, and kidney failure has been reported.

Renal function should be evaluated prior to initiation of Asacol treatment and periodically while using it.

Asacol joint pain

One of the common side effects reported when taking Mesalamine 400 mg is joint pain.

How much is the Asacol price in Canada? 

Prescription Point assures affordability on all the medications we offer including Asacol 400 mg. Check the top of this page for the list of our prices.

Frequently asked questions about Asacol

What are Asacol side effects long term use?

Asacol is a safe medication for long-term use. However, it is impossible to say that it is 100% safe. This should not be given to people with known renal problems. The most frequent problem is blood dyscrasias, which means changes can occur that affect the blood and/or bone marrow and some of the elements of the blood. This could be manifested by bruising, unexplained bleeding, anemia, or sore throat.

Does Asacol cause hair loss? 

Hair loss is common among patients with inflammatory bowel disease (IBD). Lower odds of hair loss were associated with Mesalamine and anti-TNF medications. 

Additional information

Brand Name:


Scientific Name:


Other Names:

Asacol, Mesacol



Quantities Available:

100, 150, 180, 200


DR Tablet, Delayed Release Tablet

The information above is provided by third parties to for Asacol (Mesalamine). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.