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Adcirca (tadalafil) 

Indications 

• Adcirca is used to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the vessels carrying blood to the lungs. 
• It helps improve exercise ability in patients with PAH. 
• Adcirca is prescribed to alleviate symptoms such as shortness of breath, dizziness, and fatigue associated with PAH. 

Dosage and Administration 

• Take Adcirca exactly as prescribed by your doctor, typically once daily. 
• Swallow the tablet whole with a glass of water. 
• Take Adcirca at the same time each day to maintain an even level in your bloodstream. 
• Follow your doctor’s instructions regarding the duration of therapy. 
• Inform your doctor if you have any changes in your health or new symptoms. 
• Do not take Adcirca more than once per day. 
• Avoid splitting, crushing, or chewing tablets. 
• Do not skip doses or stop taking Adcirca without consulting your doctor. 
• Avoid taking Adcirca with other medications for erectile dysfunction unless specifically advised by your doctor. 
• Do not consume excessive amounts of alcohol while taking Adcirca, as this can increase the risk of side effects. 

Mechanism of Action 

Adcirca contains tadalafil, which is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing the blood vessels in the lungs, allowing blood to flow more easily. This reduction in pulmonary blood pressure helps improve your ability to exercise and decreases the symptoms of PAH. 

Contraindications 

• Do not take Adcirca if you are allergic to tadalafil or any of its ingredients. 
• Avoid Adcirca if you are taking nitrates for chest pain, as this can cause a severe drop in blood pressure. 
• Do not use Adcirca if you have severe liver or kidney disease unless your doctor advises otherwise. 
• Avoid taking Adcirca if you have a history of heart conditions such as recent heart attack or stroke. 
• Do not use Adcirca if you have uncontrolled high or low blood pressure. 

Side Effects 

Common Side Effects 

• Headache 
• Muscle pain 
• Back pain 
• Stuffy or runny nose 
• Flushing 

Serious Side Effects 

• Sudden vision loss in one or both eyes 
• Sudden hearing loss or ringing in the ears 
• Chest pain or heavy feeling, pain spreading to the arm or shoulder 
• Shortness of breath 
• Irregular heartbeat 

Precautions 

• Inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements. 
• Notify your doctor if you have any medical condition, especially heart problems, high or low blood pressure, liver or kidney disease, or any vision issues. 
• Report any sudden vision or hearing changes to your doctor immediately. 
• Discuss the risks and benefits of using Adcirca if you have a history of priapism (prolonged erection) or conditions that predispose you to priapism. 
• Avoid driving or operating heavy machinery until you know how Adcirca affects you, as it can cause dizziness. 
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Adcirca with your doctor. 

Storage Instructions 

• Store Adcirca at room temperature, between 20°C to 25°C (68°F to 77°F). 
• Keep the tablets in their original container, tightly closed. 
• Store Adcirca out of reach of children and pets. 
• Protect the tablets from moisture and light. 
• Do not use Adcirca after the expiration date on the package. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022332s007lbl.pdf