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Combivent Respimat (ipratropium bromide and albuterol)

Indications

• Combivent Respimat inhaler is indicated for the treatment of chronic obstructive pulmonary disease (COPD) in patients who require a second bronchodilator.
• It helps to relieve bronchospasm and improve breathing in individuals with COPD, including chronic bronchitis and emphysema.

Dosage and Administration

• Use Combivent Respimat exactly as prescribed by your doctor, typically one inhalation four times daily.
• Prime the inhaler before the first use by actuating the inhaler until a mist is visible, then repeat three more times.
• Prime the inhaler again if it has not been used for more than three days (one spray) or more than 21 days (repeat the initial priming).
• Insert the cartridge into the inhaler following the instructions provided in the packaging.
• Turn the base until it clicks to load a dose.
• Breathe out fully, place the mouthpiece in your mouth, and inhale deeply and slowly while pressing the dose-release button.
• Hold your breath for 10 seconds or as long as comfortable after inhaling the medication.
• Do not exceed the prescribed dose of Combivent Respimat or use it more frequently than directed by your doctor.
• Avoid spraying the medication into your eyes as it can cause irritation or other side effects.
• Do not stop using Combivent Respimat abruptly without consulting your doctor, even if you feel better, as it may worsen your condition.

Mechanism of Action

Combivent Respimat contains Ipratropium Bromide and Albuterol, which are bronchodilators. Ipratropium bromide is an anticholinergic that helps to relax and open the airways in the lungs. Albuterol is a beta-agonist that also relaxes and widens the airways, making it easier to breathe.

Contraindications

• Do not use Combivent Respimat if you have a known allergy to ipratropium, albuterol, or any other ingredients in the inhaler.
• Avoid Combivent Respimat if you have a history of hypersensitivity to atropine or other related drugs.
• Consult your doctor before using Combivent Respimat if you have heart condition, high blood pressure, diabetes, glaucoma, or thyroid disorders.

Side Effects

Common Side Effects:

• Headache
• Dizziness
• Dry mouth
• Cough
• Nervousness or tremors

Serious Side Effects:

• Chest pain or palpitations
• Rapid or irregular heartbeat
• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Worsening of breathing problems (paradoxical bronchospasm)
• Eye pain or vision changes if sprayed in the eyes

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Combivent Respimat.
• Be cautious when using other bronchodilators or medications that affect heart rhythm, as they may interact with Combivent Respimat.
• Monitor for signs of worsening breathing problems or chest pain, and report these symptoms to your doctor immediately.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Combivent Respimat with your healthcare provider.

Storage Instructions

• Store Combivent Respimat inhaler at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the inhaler in its original packaging until ready to use.
• Do not expose the inhaler to extreme heat or open flames, as it is pressurized and may explode.
• Keep Combivent Respimat out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021747s001lbl.pdf