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Pepcid (famotidine)

Indications

Pepcid is indicated for:

• Short-term treatment of active duodenal ulcer.
• Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of acute ulcers.
• Treatment of active benign gastric ulcer.
• Maintenance therapy for gastric ulcer patients at reduced dosage after healing of acute ulcers.
• Treatment of gastroesophageal reflux disease (GERD).
• Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome).
• Relief of heartburn, acid indigestion, and sour stomach.

Dosage and Administration

• Take Pepcid exactly as prescribed by your doctor. If you take Pepcid once daily, it is usually recommended to take it at bedtime.
• Swallow the tablet whole with a glass of water.
• Take this tablet with or without food.
• Follow your doctor’s instructions carefully for the dosage and duration of treatment.
• Do not crush or chew the tablets.
• Do not take this tablet for longer than recommended without consulting your doctor.
• Do not stop taking this tablet suddenly without medical advice.

Mechanism of Action

Pepcid works by blocking histamine H2 receptors in the stomach lining. By inhibiting the action of histamine, Pepcid reduces the production of stomach acid, thereby helping to relieve symptoms associated with ulcers, GERD, and other conditions related to excessive stomach acid secretion.

Contraindications

Do not use Pepcid if you have:

• Known hypersensitivity to Famotidine or any component of the formulation.

Side Effects

Common Side Effects:

• Headache
• Dizziness
• Constipation
• Diarrhea
• Nausea

Serious Side Effects:

• Allergic reactions (rash, itching, swelling, difficulty breathing)
• Irregular heartbeat
• Confusion or hallucinations
• Severe stomach pain
• Signs of liver problems (e.g., dark urine, yellowing of the eyes or skin)

Precautions

• Use caution if you have renal impairment, as your doctor may need to adjust your dosage.
• Use Pepcid with caution if you have hepatic impairment, as it is primarily metabolized in the liver.
• Discuss with your doctor the risks and benefits of long-term use of Pepcid, as it may increase the risk of certain side effects, such as bone fractures or vitamin B12 deficiency.
• Inform your doctor about all the medications you take, including prescription, over-the-counter, herbal, or dietary supplements, as Pepcid may interact with other drugs.
• Use Pepcid during pregnancy or breastfeeding only if clearly needed and under the supervision of a healthcare professional.

Storage Instructions

Store Pepcid at room temperature between 20°C to 25°C (68°F to 77°F).

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019462s039lbl.pdf