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Aciphex (rabeprazole)

Indications

• Treatment of symptoms such as heartburn and acid regurgitation associated with GERD.
• Healing and maintenance of the esophagus lining that has been damaged due to acid reflux.
• Management of conditions where the stomach produces too much acid.
• Treatment of ulcers in the small intestine, promoting healing and reducing pain.

Dosage and Administration

• Take the tablet as directed by your doctor, usually once daily.
• Swallow the tablet whole with water; do not crush, chew, or split it.
• Take Aciphex with or without food.
• Do not exceed the recommended dose prescribed by your healthcare provider.
• Avoid taking Aciphex with alcohol, which can increase stomach acid and irritation.
• Do not stop taking the medication abruptly without consulting your doctor.

Mechanism of Action

Rabeprazole, the active ingredient in Aciphex, is a proton pump inhibitor (PPI). It works by blocking the enzyme in the stomach wall that produces acid. By reducing the amount of acid in the stomach, rabeprazole helps to heal acid-related damage to the stomach and esophagus, prevent ulcers, and improve symptoms such as heartburn and difficulty swallowing.

Contraindications

• Allergic Reaction: Do not use if you are allergic to rabeprazole, other PPIs, or any ingredients in Aciphex.
• Pregnancy and Breastfeeding: Consult a healthcare provider before using if you are pregnant or breastfeeding.
• Severe Liver Disease: Avoid using the medication if you have severe liver impairment unless advised by a doctor.
• Use of Rilpivirine: Do not take Aciphex with rilpivirine-containing products due to potential interactions.

Side Effects

Common Side Effects:

• Headache
• Diarrhea
• Nausea
• Abdominal pain
• Constipation
• Flatulence

Serious Side Effects:

• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing)
• Severe intestinal condition (Clostridium difficile-associated diarrhea)
• Bone fractures (associated with long-term, high-dose use)
• Low magnesium levels (symptoms include muscle spasms, irregular heartbeat, seizures)

Precautions

• Long-Term Use: Long-term use may increase the risk of bone fractures, particularly in the elderly. Discuss with your doctor if you need to take it for an extended period.
• Magnesium Levels: Monitor magnesium levels if you are on long-term treatment, as low levels can lead to serious health issues.
• Vitamin B12 Deficiency: Long-term use may result in vitamin B12 deficiency; supplements may be needed.
• Other Medications: Inform your doctor about all other medications you are taking to avoid potential interactions.
• Liver Function: Use with caution if you have liver problems, as dosage adjustments may be necessary.

Storage Instructions

• Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep away from excessive moisture; do not store in the bathroom.
• Protect from light to maintain efficacy.
• Keep out of reach of children to prevent accidental ingestion.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020973s039lbl.pdf