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Amitiza (lubiprostone)

Indications

• Chronic Idiopathic Constipation (CIC) in Adults: Amitiza is prescribed for adults experiencing long-term constipation without a known cause, improving bowel movement frequency and easing stool passage.
• Irritable Bowel Syndrome with Constipation (IBS-C) in Women Aged 18 and Older: This medication helps alleviate constipation-predominant IBS in adult women, reducing abdominal pain and discomfort.
• Opioid-Induced Constipation (OIC) in Adults with Chronic, Non-Cancer Pain: Amitiza assists in managing constipation caused by long-term opioid use, without affecting the pain-relief benefits of opioids.

Dosage and Administration

• Take Amitiza with food and water to reduce the risk of nausea.
• Swallow the capsules whole; do not break, chew, or crush them.
• Follow your healthcare provider’s prescribed dosage exactly.
• Do not take Amitiza if you have severe diarrhea.
• Avoid taking the medication on an empty stomach.
• Do not stop taking Amitiza suddenly without consulting your doctor.

Mechanism of Action

Amitiza works by activating chloride channels in the intestines. This action increases fluid secretion into the intestinal lumen, which softens stool, promotes bowel movements, and helps relieve symptoms of constipation.

Contraindications

• Known Allergy to Lubiprostone: Do not use it if you have had an allergic reaction to Lubiprostone.
• Mechanical Gastrointestinal Obstruction: Avoid taking Amitiza if there is a known or suspected blockage in your intestines.
• Severe Diarrhea: Do not use Amitiza if you are currently experiencing severe diarrhea, as it may worsen your condition.

Side Effects

Common Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Bloating
• Headache

Serious Side Effects

• Severe diarrhea
• Difficulty breathing or chest tightness shortly after taking a dose
• Swelling of the face, lips, tongue, or throat
• Severe allergic reactions

Precautions

• Pregnancy and Breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Liver Impairment: Patients with liver issues may require dosage adjustments; discuss with your healthcare provider.
• Severe Diarrhea: If you develop severe diarrhea, stop taking Amitiza and contact your doctor.
• Low Blood Pressure: Be cautious if you have low blood pressure or are taking medications that lower blood pressure, as Amitiza may exacerbate this.

Storage Instructions

• Store Amitiza at room temperature, between 68°F and 77°F (20°C and 25°C).
• Keep the medication in its original container, tightly closed, and out of reach of children.
• Protect it from moisture and light; do not store it in the bathroom.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021908s015lbl.pdf