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Maxalt (rizatriptan)

Indications

Maxalt tablets provide relief from migraine headaches, with or without aura, by narrowing blood vessels in the brain and reducing substances that trigger migraine pain.

Dosage and Administration

• Take Maxalt exactly as prescribed by your doctor.
• Swallow the tablet whole with water. If your headache returns after the initial dose, you may take a second tablet at least 2 hours after the first dose.
• Take the medication as soon as you notice migraine symptoms.
• Keep track of your migraine attacks and response to treatment.
• Do not crush, chew, or break the tablets.
• Do not exceed the recommended dose or take more than 2 tablets in a 24-hour period.
• Do not use Maxalt to prevent migraines or cluster headaches.
• Do not use Maxalt if you have taken ergotamine or ergot-type medications within the past 24 hours.

Mechanism of Action

Maxalt contains rizatriptan, which belongs to a class of drugs called triptans. It works by narrowing blood vessels in the brain and reducing the release of certain natural substances that cause migraine symptoms, including pain, nausea, and sensitivity to light and sound.

Contraindications

• Allergy to Rizatriptan: Do not use Maxalt if you have a known hypersensitivity to rizatriptan or any of the inactive ingredients in the tablets.
• History of Heart Disease or Stroke: Avoid use in patients with a history of heart disease, coronary artery vasospasm, or stroke.
• Uncontrolled High Blood Pressure: Not recommended for patients with uncontrolled hypertension.
• Use with MAO Inhibitors: Do not use Maxalt within 2 weeks of discontinuing MAO inhibitors due to the risk of serotonin syndrome.
• Severe Liver Disease: Use caution in patients with severe hepatic impairment.

Side Effects

Common Side Effects

• Dizziness
• Drowsiness
• Fatigue
• Nausea
• Dry mouth
• Sensation of tingling or warmth

Serious Side Effects

• Chest pain or tightness
• Fast or pounding heartbeat
• Shortness of breath
• Sudden numbness or weakness, especially on one side of the body
• Vision changes
• Severe abdominal pain

Precautions

• Inform Your Doctor About All Medications: Ensure your doctor knows about all the medications you are taking to avoid drug interactions.
• Monitor for Cardiovascular Events: Report any symptoms of heart attack or stroke to your doctor immediately.
• Pregnancy and Breastfeeding: Consult your doctor before using Maxalt if you are pregnant, planning to become pregnant, or breastfeeding.
• Avoid Driving or Operating Machinery: Maxalt may cause dizziness or drowsiness, so avoid activities that require mental alertness until you know how the medication affects you.
• Limit Alcohol Consumption: Alcohol may increase the risk of side effects such as dizziness or drowsiness.

Storage Instructions

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Protect from moisture and light.
• Keep in the original container tightly closed.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the container.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020864s013lbl.pdf