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Imitrex (sumatriptan) 

Indications 

• Acute Migraine Attacks 
• Used to treat acute migraine headaches with or without aura. Imitrex provides relief from the headache, nausea, and sensitivity to light and sound associated with migraines. 
• Cluster Headaches 
• Effective in the acute treatment of cluster headaches, which are severe, one-sided headaches that occur in clusters over a period of time. 

Dosage and Administration 

• Take Imitrex exactly as prescribed by your healthcare provider. 
• Take the tablet as soon as you notice migraine or cluster headache symptoms. 
• Swallow the tablet whole with a glass of water. 
• Follow the prescribed maximum dose (usually not more than 200 mg in 24 hours for migraines). 
• Take a second dose after at least 2 hours if the headache comes back after initial relief. 
• Do not crush, chew, or break the tablets. 
• Do not use Imitrex for more than 4 headache episodes in a 30-day period without consulting your doctor. 
• Avoid driving or operating heavy machinery until you know how Imitrex affects you, as it can cause dizziness or drowsiness. 

Mechanism of Action 

Imitrex (sumatriptan) works by stimulating serotonin receptors in the brain, which leads to the constriction of blood vessels and reduction of inflammation around the brain. This helps to alleviate the pain and other symptoms associated with migraine headaches and cluster headaches. 

Contraindications 

• Allergic Reactions: Do not use if you are allergic to sumatriptan or any other ingredients in Imitrex. 
• Heart Problems: Avoid use if you have a history of heart problems, including heart attack, angina (chest pain), or coronary artery disease. 
• Stroke or TIA: Not recommended for patients with a history of stroke or transient ischemic attack (TIA). 
• Severe Liver Disease: Contraindicated in patients with severe liver impairment. 
• Uncontrolled High Blood Pressure: Do not use if you have uncontrolled high blood pressure. 
• Use of MAO Inhibitors: Avoid use if you have taken a monoamine oxidase (MAO) inhibitor in the last 14 days. 
• Peripheral Vascular Disease: Not suitable for individuals with peripheral vascular disease. 

Side Effects 

Common Side Effects: 

• Dizziness 
• Drowsiness 
• Fatigue 
• Tingling or numbness 
• Warmth or redness under the skin 
• Nausea 

Serious Side Effects: 

• Chest pain or pressure 
• Irregular heartbeat 
• Severe stomach pain 
• Shortness of breath 
• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing) 

Precautions 

• Inform About Medical History: Inform your healthcare provider about your complete medical history, especially if you have heart disease, liver problems, or high blood pressure. 
• Check Drug Interactions: Discuss all medications you are currently taking, including prescription, over-the-counter drugs, and supplements, to avoid interactions. 
• Limit Usage: Do not overuse Imitrex, as it can lead to medication-overuse headaches. 
• Monitor for Heart-Related Symptoms: Be aware of heart-related symptoms such as chest pain, shortness of breath, or irregular heartbeat, and seek immediate medical attention if they occur. 
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Imitrex in these conditions is not fully established. 

Storage Instructions 

• Store at room temperature between 20°C to 25°C (68°F to 77°F). 
• Keep in a dry place away from moisture and direct sunlight. 
• Store the tablets in their original packaging until it’s time to take them. 
• Keep out of the reach of children and pets. 
• Do not use the tablets beyond their expiration date. Dispose of any expired medication properly. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020080s049lbl.pdf