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Exelon (rivastigmine)

Indications

Exelon (Rivastigmine) capsules are prescribed for the following conditions:

• Alzheimer’s Disease: Used to treat mild to moderate dementia associated with Alzheimer’s disease.
• Parkinson’s Disease Dementia: Helps manage mild to moderate dementia in patients with Parkinson’s disease.

Dosage and Administration

• Follow your doctor’s prescription exactly. Exelon capsules are typically taken twice daily with food.
• Swallow the capsules whole with water.
• Start low and go slow. Dosage is usually started low and gradually increased as directed by your doctor to minimize side effects.
• Take Exelon at the same time each day to maintain an even level of medication in your body.
• Do not crush, chew, or break the capsules.
• Do not skip doses. Missing doses can reduce the effectiveness of the treatment.
• Do not take more than the prescribed amount. Overdose can increase the risk of severe side effects.

Mechanism of Action

Exelon (Rivastigmine) is a cholinesterase inhibitor. It works by increasing the levels of acetylcholine, a chemical messenger in the brain that is important for memory and cognitive function. By inhibiting the enzymes that break down acetylcholine, Exelon helps improve the symptoms of dementia in Alzheimer’s and Parkinson’s diseases.

Contraindications

Exelon should not be used if you:

• Are Allergic to Rivastigmine: Any known hypersensitivity to Rivastigmine or any component of Exelon capsules.
• Have Severe Liver Disease: Significant liver impairment can be exacerbated by rivastigmine.
• Have a History of Severe Skin Reactions: Such as severe allergic dermatitis caused by rivastigmine.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Loss of appetite
• Weight loss
• Dizziness
• Headache

Serious Side Effects:

• Severe Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing.
• Gastrointestinal Issues: Severe nausea, vomiting, or diarrhea that leads to dehydration.
• Heart Problems: Slow or irregular heartbeat, fainting.
• Severe Skin Reactions: Blistering, peeling, or severe redness of the skin.

Precautions

• Monitor Health Changes: Be aware of any unusual changes or reactions in your body and inform your doctor immediately.
• Regular Check-ups: Regular follow-up visits with your doctor are important to monitor your condition and the effectiveness of the treatment.
• Inform About All Medications: Provide a full list of all medications, including over-the-counter drugs and supplements, to your healthcare provider.
• Monitor Weight: Regularly monitor your weight and inform your doctor if you notice significant weight loss.
• Avoid Dehydration: Drink plenty of fluids, especially if you experience nausea or vomiting, to prevent dehydration.

Storage Instructions

• Keep Exelon capsules at a temperature between 68°F to 77°F (20°C to 25°C).
• Store in a dry place; avoid bathrooms and kitchens where humidity is high.
• Store the capsules in their original container, tightly closed, to protect them from moisture and light.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020823s036,021025s024lbl.pdf