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Namenda (memantine)

Indications

Namenda is prescribed to help manage the symptoms of moderate to severe Alzheimer’s disease. It works to improve memory, awareness, and the ability to perform daily functions.

Dosage and Administration

• Take Namenda exactly as prescribed by your healthcare provider, typically once or twice daily.
• Take the medication with or without food, based on your preference or doctor’s advice.
• Swallow the tablets whole.
• Take Namenda at the same time each day to maintain steady levels of the medication in your body.
• Avoid adjusting your dosage without consulting your healthcare provider, as it can affect the medication’s effectiveness and safety.
• Do not crush, chew, or split the tablets to ensure proper dosage delivery.
• Avoid skipping doses as it can reduce the effectiveness of Namenda in managing Alzheimer’s symptoms.
• Do not take a double dose to make up for a missed one. Simply take the next dose at the scheduled time.

Mechanism of Action

Namenda (Memantine) works by regulating the activity of glutamate, a neurotransmitter involved in learning and memory. Memantine acts as an NMDA receptor antagonist, helping to prevent excessive glutamate activity that can lead to neuronal damage and cognitive decline in Alzheimer’s disease.

Contraindications

• Known Hypersensitivity to Memantine: Do not take Namenda if you have a known allergy to Memantine or any of its components.
• Severe Kidney Impairment: Patients with severe kidney problems should not use Namenda as it can lead to increased side effects.

Side Effects

Common Side Effects:

• Dizziness
• Headache
• Confusion
• Constipation
• Cough

Serious Side Effects:

• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing)
• Hallucinations
• Severe mood changes (depression, thoughts of harming yourself)
• Difficulty urinating

Precautions

• Inform About All Medications: Share a complete list of your current medications with your doctor to avoid harmful interactions.
• Monitor for Severe Mood Changes: Contact your healthcare provider if you experience severe mood changes or thoughts of self-harm.
• Use Caution if You Have Seizure Disorders: Discuss with your doctor if you have a history of seizures before starting Namenda.
• Avoid Operating Heavy Machinery if Drowsy: Namenda can cause dizziness or drowsiness; ensure you know how it affects you before driving or operating machinery.

Storage Instructions

• Keep Namenda tablets at 77°F (25°C); brief excursions between 59°F and 86°F (15°C to 30°C) are allowed.
• Store in the original container to protect from moisture and light.
• Store Namenda in a safe place away from children to prevent accidental ingestion.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021487s025lbl.pdf