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Accupril (quinapril)

Indications

• Accupril tablets are prescribed to treat high blood pressure (hypertension) and heart failure.
• This medication helps to lower blood pressure by relaxing blood vessels, making it easier for the heart to pump blood to the body’s organs.
• Accupril may also be used to improve survival after a heart attack and to protect the kidneys in patients with diabetes.

Dosage and Administration

• Take Accupril exactly as prescribed by your doctor.
• Swallow the tablet whole with a full glass of water.
• Take Accupril at the same time each day to maintain consistent levels in your blood.
• Inform your doctor if you have any kidney problems before starting Accupril.
• Do not crush, chew, or break Accupril tablets, as this may affect their effectiveness.
• Avoid missing doses; if you forget a dose, take it as soon as you remember, but do not double up on doses.
• Do not stop taking Accupril abruptly without consulting your doctor, as this may lead to a sudden increase in blood pressure.

Mechanism of Action

Quinapril, the active ingredient in Accupril, is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the action of ACE, an enzyme that converts angiotensin I to angiotensin II. By inhibiting this enzyme, quinapril prevents the production of angiotensin II, a hormone that causes blood vessels to constrict. This results in vasodilation (widening of blood vessels), which helps lower blood pressure and improve blood flow.

Contraindications

• Do not take Accupril if you have a known allergy to quinapril or any components of the tablets.
• Avoid Accupril if you have a history of angioedema (swelling of the face, lips, tongue, or throat) related to previous ACE inhibitor therapy.
• Do not use Accupril if you are pregnant or planning to become pregnant, as it may cause harm to the unborn baby.
• Avoid Accupril if you have severe kidney disease or are on dialysis without consulting your doctor.

Side Effects

Common Side Effects

• Cough
• Dizziness
• Fatigue
• Headache
• Nausea
• Rash

Serious Side Effects

• Angioedema, characterized by swelling of the face, lips, tongue, or throat
• Severe allergic reactions, such as difficulty breathing or swallowing
• Decreased kidney function, indicated by changes in urine output or swelling in the legs or ankles
• Hyperkalemia (high potassium levels), with symptoms such as weakness, confusion, irregular heartbeat, or numbness/tingling

Precautions

• Inform your doctor if you have a history of kidney or liver problems before starting Accupril.
• Report any signs of allergic reactions or serious side effects to your doctor immediately.
• Use caution when driving or operating machinery, as Accupril may cause dizziness or lightheadedness.
• Avoid excessive alcohol consumption while taking Accupril, as it may increase the risk of side effects.
• Monitor your blood pressure and kidney function regularly while taking Accupril.

Storage Instructions

• Store Accupril tablets at room temperature, away from moisture and heat.
• Keep the tablets in their original packaging to protect them from light.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019885s035lbl.pdf