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Cetrotide (cetrorelix acetate)

Indications

• Cetrotide is prescribed to prevent premature ovulation during assisted reproductive technology procedures like in vitro fertilization (IVF).
• This medication controls the timing of ovulation to enhance the success of fertility treatment.
• It acts by blocking the effects of a hormone in your body called gonadotropin-releasing hormone (GnRH).

Dosage and Administration

• Administer Cetrotide subcutaneously under your skin exactly as directed by your healthcare provider.
• Follow the prescribed dosing schedule meticulously as instructed by your doctor.
• Do not administer more or less than the dose prescribed for you.
• Avoid mixing Cetrotide with other medications in the same injection.

Mechanism of Action

Cetrotide functions by blocking the action of GnRH, a natural hormone in your body. This hormone is responsible for regulating your menstrual cycle and ovulation. By obstructing GnRH, Cetrotide prevents premature ovulation during fertility treatment.

Contraindications

• Do not use Cetrotide if you are allergic to cetrorelix or any of the ingredients in the medication.
• Avoid using Cetrotide if you have severe kidney disease.
• Do not use this medication if you are pregnant or breastfeeding.
• Avoid Cetrotide if you have certain hormone-related cancers like breast or ovarian cancer.

Side Effects

Common Side Effects

• Headaches
• Nausea
• Redness, pain, or swelling at the injection site
• Abdominal discomfort
• Hot flashes

Serious Side Effects

• Severe allergic reactions (difficulty breathing, swelling of face or throat)
• Ovarian hyperstimulation syndrome (severe pelvic pain, swelling of hands or legs, stomach pain, nausea, vomiting)
• Ovarian torsion (sudden or severe pelvic pain, nausea, vomiting)

Precautions

• Before starting Cetrotide, inform your healthcare provider about all the medications you are currently taking.
• Follow all instructions meticulously to ensure proper use and effectiveness of the medication.
• Promptly report any unusual symptoms or side effects to your doctor.
• Until you understand how Cetrotide affects you, avoid engaging in activities that require mental alertness.

Storage Instructions

• Store Cetrotide vials in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C).
• Protect the vials from light exposure. Do not freeze them.
• Keep the vials in the original carton until you are ready to use them.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21197lbl.pdf