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Zocor (simvastatin) 

Indications 

• Zocor is used to lower high levels of cholesterol in your blood, particularly low-density lipoprotein (LDL) cholesterol, known as “bad” cholesterol. 
• This medication helps reduce the risk of heart disease and stroke by lowering cholesterol levels and other fats in your blood. 
• Zocor can help lower high levels of triglycerides, a type of fat in your blood.
• It treats combined high levels of cholesterol and triglycerides. 

Dosage and Administration 

• Follow your doctor’s instructions exactly when taking Zocor. 
• Swallow the tablet whole with a glass of water. 
• Take Zocor in the evening, as cholesterol production in the body is highest at night. 
• Combine taking Zocor with a cholesterol-lowering diet, exercise, and weight control. 
• Do not skip doses; missing doses can reduce the effectiveness of the medication. 
• Avoid large amounts of grapefruit juice, as it can interfere with the medication and increase the risk of side effects. 
• Do not take an extra tablet to make up for a missed dose. 
• Avoid alcohol, as it can increase the risk of liver damage while taking Zocor.

Mechanism of Action 

Simvastatin, the active ingredient in Zocor, works by inhibiting an enzyme called HMG-CoA reductase. This enzyme is crucial for the production of cholesterol in the liver. By blocking this enzyme, simvastatin reduces the amount of cholesterol produced, leading to lower blood cholesterol levels. Additionally, it helps the liver remove cholesterol from the blood. 

Contraindications 

• Do not take Zocor if you are allergic to simvastatin or any other ingredients in the tablet. 
• Avoid Zocor if you have active liver disease or unexplained persistent elevations in liver enzymes. 
• Do not use Zocor if you are pregnant, planning to become pregnant, or breastfeeding. 
• Avoid Zocor if you are taking medications that interact negatively with simvastatin, such as certain antifungals, antibiotics, and HIV protease inhibitors. 

Side Effects 

Common Side Effects 

• Headache 
• Nausea 
• Constipation 
• Stomach pain 
• Upper respiratory infections 
• Muscle pain 

Serious Side Effects 

• Severe muscle pain, tenderness, or weakness 
• Yellowing of the skin or eyes (jaundice) 
• Severe abdominal pain 
• Unexplained fatigue or weakness 
• Dark-colored urine 
• Allergic reactions like rash, itching, or swelling

Precautions 

• Have your liver function tested regularly to monitor for potential liver damage. 
• Inform your doctor immediately if you experience any unexplained muscle pain, tenderness, or weakness. 
• Inform your doctor about all medications you are taking to avoid harmful interactions. 
• Use effective contraception to avoid pregnancy while taking Zocor. 
• If you have diabetes, monitor your blood sugar levels as Zocor can increase blood sugar levels. 

Storage Instructions 

• Store Zocor tablets at room temperature, between 20°C and 25°C (68°F to 77°F). 
• Store in a dry place away from direct light. 
• Ensure that children cannot access the medication. 
• Check the expiration date and do not use it if the medicine is out of date.

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019766s078lbl.pdf