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Indications

  • Toprol XL is used to treat various cardiovascular conditions by reducing the heart rate and lowering blood pressure. The indications include:
  • Hypertension: Helps lower high blood pressure to prevent strokes, heart attacks, and kidney problems.
  • Angina Pectoris: Treats chest pain related to heart disease by improving blood flow to the heart muscle.
  • Heart Failure: Manages chronic heart failure to improve survival and reduce hospitalizations.
  • Prevention of Heart Attacks: Helps to prevent heart attacks in patients with a history of myocardial infarction.

Ingredients

  • Active Ingredient: Metoprolol Succinate
  • Inactive Ingredients: Silicon dioxide, cellulose compounds, polyethylene glycol, sodium stearyl fumarate, titanium dioxide, and other inactive components

Dosage and Administration

  • Take Toprol XL exactly as prescribed by your healthcare provider, typically once daily.
  • Swallow the tablet whole with a glass of water. If difficulty swallowing, the tablet may be split in half, but both halves should be swallowed without chewing or crushing.
  • Take Toprol XL with or immediately after a meal.
  • Follow your doctor’s instructions regarding dosage adjustments and regular monitoring of your condition.
  • Inform your doctor of all other medications or supplements you are taking to avoid potential interactions.
  • Do not crush or chew the extended-release tablet, as this can release the drug all at once, increasing the risk of side effects.
  • Avoid abrupt discontinuation of Toprol XL without consulting your healthcare provider, as this can worsen your condition.
  • Do not take Toprol XL if you have severe bradycardia (slow heart rate) or certain heart conduction disorders without consulting your doctor.

Mechanism of Action

Metoprolol succinate, the active ingredient in Toprol XL, is a beta-1-selective adrenoceptor blocking agent. It works by blocking beta-1 adrenergic receptors in the heart, leading to a decrease in heart rate, cardiac output, and the release of renin from the kidneys. This results in lower blood pressure and reduced oxygen demand by the heart muscle, thereby managing conditions like hypertension, angina, and heart failure.

Contraindications

  • Do not use Toprol XL if you are allergic to metoprolol succinate or any other beta-blockers.
  • Avoid using Toprol XL if you have severe heart block, sick sinus syndrome, or severe peripheral arterial circulatory disorders.
  • Consult your healthcare provider before using Toprol XL if you have a history of severe bradycardia, hypotension, or cardiogenic shock.
  • Inform your doctor if you have asthma, chronic obstructive pulmonary disease (COPD), or other respiratory conditions.
  • Do not use Toprol XL if you are pregnant or breastfeeding without consulting your healthcare provider.

Side Effects

Common Side Effects:

  • Dizziness
  • Tiredness
  • Depression
  • Nausea
  • Dry mouth
  • Stomach pain

Serious Side Effects:

  • Severe allergic reactions (e.g., rash, itching, swelling of the face or throat, difficulty breathing)
  • Severe dizziness or fainting
  • Shortness of breath
  • Swelling of the ankles or feet
  • Irregular or very slow heartbeat

Precautions

  • Inform your doctor about any other medical conditions you have, especially heart, liver, or lung diseases.
  • Regularly monitor your blood pressure and heart rate as advised by your doctor.
  • Use caution when engaging in activities that require alertness, such as driving, until you know how Toprol XL affects you.
  • Discuss with your doctor any plans for surgery or dental procedures.
  • Follow your healthcare provider’s advice on lifestyle modifications, such as diet and exercise, to complement your treatment.

Storage Instructions

  • Store Toprol XL tablets at room temperature between 20°C to 25°C (68°F to 77°F).
  • Keep the tablets in their original container, tightly closed, and protected from moisture and light.
  • Keep out of reach of children and pets.

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References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019962s041lbl.pdf

Additional information

Brand Name:

Toprol XL

Scientific Name:

Metoprolol Succinate

Other Names:

Betaloc CR, Metocard XL, Metoprolol Succinate, Saneloc, Seloken XL, Supermet XL, Toprol XL

Strength(s):

12.5mg, 25mg, 50mg, 100mg, 200mg

Quantities Available:

90, 100, 180

Formulation:

ER Tablet, Extended Release Capsule, Extended ReleaseTablet, Tablet

The information above is provided by third parties to Prescriptionpoint.com for Toprol XL (Metoprolol Succinate). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.


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