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Rifadin (rifampin) 

Indications 

• Rifadin is used as part of a combination therapy to treat all forms of tuberculosis. 
• It is also used to eliminate Neisseria meningitidis from the nasopharynx, reducing the risk of spreading meningitis. 

Dosage and Administration 

• Take Rifadin exactly as prescribed by your doctor. 
• Swallow the capsules whole with a full glass of water. 
• Take the medication on an empty stomach, either 1 hour before or 2 hours after a meal, for optimal absorption. 
• Follow your doctor’s instructions on the dosage and schedule, typically taken once daily. 
• Do not crush, chew, or break the capsules, as this can affect the drug’s effectiveness. 
• Avoid skipping doses. 
• Do not take more than the prescribed dose to prevent potential side effects or overdose. 
• Do not stop taking Rifadin without consulting your doctor, even if you feel better, to prevent the development of drug-resistant bacteria. 

Mechanism of Action 

Rifadin (Rifampin) works by inhibiting the DNA-dependent RNA polymerase in bacterial cells, preventing RNA synthesis and bacterial replication. This bactericidal action is effective against a wide range of gram-positive and gram-negative organisms, including Mycobacterium tuberculosis, the causative agent of tuberculosis. 

Contraindications 

• Do not use it if you are allergic to Rifampin or any of the ingredients in Rifadin. 
• Avoid use if you have a history of liver disease or jaundice. 
• Not recommended for individuals taking certain medications, such as protease inhibitors, which can interact with rifampin. 
• Consult your doctor if you have a history of diabetes, blood disorders, or kidney disease before taking this medication. 
• Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. 

Side Effects 

Common Side Effects: 

• Nausea 
• Vomiting 
• Diarrhea 
• Abdominal pain 
• Heartburn 
• Fatigue 
• Headache 

Serious Side Effects: 

• Signs of liver problems (yellowing of the skin or eyes, dark urine, abdominal pain) 
• Severe allergic reactions (rash, itching, swelling of the face/tongue/throat) 
• Flu-like symptoms (fever, chills, muscle aches) 
• Blood disorders (unusual bleeding or bruising, pale skin, shortness of breath) 
• Severe skin reactions (blistering, peeling skin) 

Precautions 

• Regularly monitor liver function and complete blood counts as recommended by your healthcare provider. 
• Be aware that Rifadin can cause a red-orange discoloration of bodily fluids, including urine, sweat, tears, and saliva; this is harmless but can stain clothing and contact lenses. 
• Use non-hormonal birth control methods, as Rifadin can reduce the effectiveness of hormonal contraceptives. 

Storage Instructions 

• Store Rifadin capsules at room temperature between 68°F and 77°F (20°C and 25°C). 
• Keep the medication in its original container, tightly closed, and away from moisture and light. 
• Do not store it in the bathroom to avoid exposure to humidity. 
• Keep out of reach of children and pets. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/050420s080,050627s023lbl.pdf