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Prinivil (lisinopril)

Indications

• Hypertension: Prinivil is used to treat high blood pressure (hypertension). Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems.
• Heart Failure: It is used to manage heart failure, improving survival after a heart attack and reducing symptoms such as shortness of breath and swelling.
• Post-Heart Attack: Prinivil can improve survival rates following a heart attack by reducing the workload on the heart.

Dosage and Administration

• Take Prinivil exactly as prescribed by your healthcare provider.
• Take the tablet at the same time each day, with or without food, to maintain an even level of the medication in your blood.
• Drink plenty of fluids unless otherwise directed by your doctor, as dehydration can increase the risk of side effects.
• Monitor your blood pressure regularly to ensure the medication is working effectively.
• Do not stop taking Prinivil suddenly without consulting your doctor, as this can cause a sudden increase in blood pressure.
• Avoid using salt substitutes or potassium supplements without your doctor’s advice, as Prinivil can increase potassium levels.
• Do not take Prinivil if you are pregnant or planning to become pregnant, as it can harm an unborn baby.
• Do not take it if you have a history of angioedema related to previous ACE inhibitor therapy.

Mechanism of Action

Prinivil is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action relaxes blood vessels, reduces blood pressure, and decreases the heart’s workload.

Contraindications

• Do not use Prinivil if you have a history of angioedema related to previous ACE inhibitor treatment.
• Avoid if you have severe kidney disease or are undergoing dialysis.
• Do not use it if you are pregnant, planning to become pregnant, or breastfeeding.
• Not recommended for individuals with a known allergy to lisinopril or any of its ingredients.

Side Effects

Common Side Effects

• Dizziness
• Headache
• Cough
• Fatigue
• Nausea

Serious Side Effects

• Severe allergic reactions (swelling of the face, lips, tongue, or throat)
• High potassium levels (hyperkalemia)
• Kidney problems
• Liver problems (jaundice, elevated liver enzymes)
• Fainting or severe dizziness

Precautions

• Inform your doctor if you have a history of kidney or liver disease before starting Prinivil.
• Regularly monitor blood pressure and kidney function through scheduled check-ups.
• Stay hydrated but avoid excessive intake of potassium-rich foods and supplements.
• Report any signs of infection (fever, sore throat) to your healthcare provider, as Prinivil can lower white blood cell counts.
• Use caution when driving or operating heavy machinery until you know how Prinivil affects you, as it can cause dizziness.

Storage Instructions

• Store Prinivil tablets at room temperature, between 15°C to 30°C (59°F to 86°F).
• Keep the tablets in their original packaging to protect them from moisture and light.
• Do not store it in the bathroom or near a sink.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019558s054lbl.pdf