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Parnate (tranylcypromine)

Indications

• Parnate tablets are prescribed for the treatment of major depressive disorder (MDD) in adults who have not responded adequately to other antidepressant therapies.

Dosage and Administration

• Take Parnate exactly as prescribed by your healthcare provider.
• Swallow the tablet whole with water.
• Take Parnate with or without food, as directed by your doctor.
• Do not crush or chew the tablet.
• Avoid consuming foods high in tyramine while taking Parnate, as this can cause a sudden and dangerous increase in blood pressure.
• Do not stop taking Parnate abruptly without consulting your doctor, as it may lead to withdrawal symptoms.

Mechanism of Action

Parnate belongs to a class of medications known as monoamine oxidase inhibitors (MAOIs). It works by inhibiting the activity of monoamine oxidase, an enzyme that breaks down neurotransmitters such as serotonin, norepinephrine, and dopamine. By increasing the levels of these neurotransmitters in the brain, Parnate helps alleviate symptoms of depression.

Contraindications

• Do not use Parnate if you have a history of hypersensitivity to tranylcypromine or other MAOIs.
• Avoid Parnate if you are taking certain medications, such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, or sympathomimetic agents, as interactions can lead to serious side effects.
• Parnate should not be used in patients with a history of pheochromocytoma (a rare tumor of the adrenal gland) or severe liver disease.

Side Effects

Common side effects

• Dizziness
• Drowsiness
• Dry mouth
• Insomnia
• Increased appetite

Serious side effects

• Hypertensive crisis (severe headache, blurred vision, chest pain, nausea)
• Seizures
• Suicidal thoughts or behaviors
• Liver toxicity (yellowing of the skin or eyes, dark urine)
• Serotonin syndrome (agitation, hallucinations, rapid heart rate)

Precautions

• Inform your doctor about all medications you are currently taking, including over-the-counter drugs and supplements.
• Follow dietary restrictions to avoid foods high in tyramine (aged cheeses, cured meats, fermented foods) while taking Parnate.
• Monitor your blood pressure regularly while on Parnate, as it may cause hypertension.

Storage Instructions

• Store Parnate tablets at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep the tablets in their original container, tightly closed, and away from moisture and heat.
• Do not store Parnate in the bathroom or near the kitchen sink where it could be exposed to moisture.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/012342s064lbl.pdf