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Orap (pimozide) 

Indications 

• Orap tablets are prescribed to treat severe psychiatric disorders such as schizophrenia and Tourette syndrome. 
• It helps control symptoms such as hallucinations, delusions, and uncontrolled movements (tics). 

Dosage and Administration 

• Take Orap exactly as prescribed by your healthcare provider. 
• Swallow the tablet whole with water. 
• Take Orap at the same time each day to maintain a consistent level in your bloodstream. 
• Do not crush, chew, or break the tablet. 
• Avoid consuming grapefruit or grapefruit juice while taking Orap, as it can increase the levels of pimozide in your blood. 

Mechanism of Action 

Orap works by blocking the action of dopamine receptors in the brain. Dopamine is a neurotransmitter involved in regulating mood and behavior. By blocking these receptors, Orap helps reduce symptoms of schizophrenia and Tourette syndrome. 

Contraindications 

• Do not take Orap if you have a history of heart rhythm problems or a prolonged QT interval on ECG. 
• Avoid Orap if you are taking certain medications that can interact with pimozide, leading to serious side effects. 
• Orap should not be used in patients with severe liver or kidney disease. 

Side Effects 

Common side effects: 

• Drowsiness 
• Dizziness 
• Dry mouth 
• Constipation 
• Weight gain 

Serious side effects: 

• Irregular heartbeat 
• Muscle stiffness 
• Tremors 
• Difficulty breathing or swallowing 
• Seizures 

Precautions 

• Inform your doctor about any other medications you are taking, including over-the-counter drugs and supplements. 
• Monitor your heart rhythm regularly while taking Orap, especially if you have a history of heart problems. 
• Avoid alcohol while taking Orap, as it can increase the risk of side effects such as drowsiness and dizziness. 

Storage Instruction

• Store Orap tablets at room temperature between 68°F to 77°F (20°C to 25°C). 
• Keep the tablets in their original container, tightly closed and away from moisture and heat. 
• Do not store Orap in the bathroom or near the kitchen sink where it could be exposed to moisture. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/017473s041lbl.pdf