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Artane (trihexyphenidyl)

Indications

• Artane is used to treat the symptoms of Parkinson’s disease, such as muscle stiffness, tremors, and poor muscle control.
• It helps manage extrapyramidal symptoms (movement disorders) caused by certain medications, particularly antipsychotics.
• Artane can improve walking ability and reduce uncontrolled movements.

Dosage and Administration

• Take Artane exactly as prescribed by your doctor, usually 3-4 times daily.
• Swallow the tablet whole or break it along the scored line to adjust the dose as directed by your doctor.
• Take your doses at the same time each day to maintain an even level of medication in your body.
• Inform your doctor about all other medications you are taking to avoid potential interactions.
• Follow your doctor’s instructions regarding regular check-ups to monitor your condition and adjust the dosage if necessary.
• Do not take more than the prescribed dose.
• Avoid stopping Artane abruptly without consulting your doctor, as this can worsen your symptoms.
• Do not crush or chew the tablets if not intend to break along the score line.

Mechanism of Action

Artane contains Trihexyphenidyl, an anticholinergic agent. It works by blocking acetylcholine, a chemical in the brain that influences muscle movement. By reducing the activity of acetylcholine, Artane helps to decrease muscle stiffness, tremors, and other Parkinson’s disease symptoms.

Contraindications

• Do not use Artane if you are allergic to Trihexyphenidyl or any of its ingredients.
• Avoid using the medication if you have untreated angle-closure glaucoma.
• Do not take it if you have severe narrowing of the gastrointestinal tract.
• Avoid using Artane if you have a bladder obstruction or other urinary retention issues without consulting your doctor.

Side Effects

Common Side Effects:

• Dry mouth
• Blurred vision
• Dizziness
• Nausea
• Constipation

Serious Side Effects:

• Severe allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing
• Confusion or hallucinations
• Fast or irregular heartbeat
• Difficulty urinating
• Severe stomach pain or constipation

Precautions

• Inform your doctor about all other medications you are using, including over-the-counter products and supplements.
• Notify your doctor if you have a history of glaucoma, heart disease, kidney disease, liver disease, or mental health conditions.
• Use caution if you are pregnant, planning to become pregnant, or breastfeeding, and discuss the risks and benefits with your doctor.
• Stay hydrated, especially in hot weather, to avoid overheating and dehydration.
• Avoid operating heavy machinery or driving until you know how Artane affects you, as it can cause dizziness and drowsiness.

Storage Instructions

• Store Artane at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original container, tightly closed.
• Store Artane out of reach of children and pets.
• Protect the tablets from moisture and light.

References

https://www.accessdata.fda.gov/drugsatfda_docs/anda/98/40254_Trihexyphenidyl%20Hydrochloride_Prntlbl.pdf