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Nozinan (methotrimeprazine)

Indications

  • Psychotic Disorders: Nozinan is used to manage symptoms of psychotic disorders such as schizophrenia, where it helps alleviate hallucinations and delusions.
  • Severe Nausea and Vomiting: Effective in treating severe nausea and vomiting, especially when other treatments have not worked.
  • Severe Anxiety: It may be prescribed for short-term management of severe anxiety when other treatments are not appropriate.

Ingredients

  • Active Ingredient: Levomepromazine
  • Inactive Ingredients: Lactose, microcrystalline cellulose, magnesium stearate, povidone, and other excipients.

Dosage and Administration

  • Take Nozinan tablets exactly as prescribed by your doctor, usually one to three times daily.
  • Swallow the tablets whole with a full glass of water. Do not crush or chew the tablets.
  • Follow your doctor’s instructions regarding dosage and frequency to manage symptoms effectively.
  • Inform your healthcare provider of any new or worsening symptoms.
  • Do not take more or less of the medication than prescribed, as it can lead to ineffective treatment or increased risk of side effects.
  • Avoid stopping the medication abruptly without consulting your doctor, as this can cause withdrawal symptoms or worsening of your condition.
  • Do not combine Nozinan with alcohol or other central nervous system depressants unless approved by your healthcare provider.
  • Do not skip doses. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double up on doses.

Mechanism of Action

Nozinan (levomepromazine) works by blocking certain chemical receptors in the brain, particularly dopamine receptors. This action helps to balance the levels of neurotransmitters involved in mood regulation and perception, thereby reducing symptoms of psychosis and controlling nausea and vomiting.

Contraindications

  • Do not use if you have a known hypersensitivity to levomepromazine or any other components of the tablets.
  • Contraindicated in patients with severe liver or kidney dysfunction as it can worsen these conditions.
  • Avoid use in patients with a history of severe blood disorders or bone marrow suppression.
  • Not recommended for use in individuals with severe cardiovascular disorders, including recent heart attack or severe heart failure.

Side Effects

Common Side Effects:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Constipation
  • Weight gain

Serious Side Effects:

  • Severe allergic reactions (e.g., rash, itching, swelling, difficulty breathing)
  • Signs of severe movement disorders (e.g., tremors, muscle stiffness)
  • Severe heart rhythm disturbances
  • Unusual bleeding or bruising
  • Signs of liver problems (e.g., yellowing of the skin or eyes)

Precautions

  • Regular monitoring of blood counts and liver function may be required during treatment.
  • Inform your doctor if you have a history of heart disease, liver or kidney problems, or blood disorders.
  • Use caution if you have a history of seizures or are at risk of them, as Nozinan can lower the seizure threshold.
  • Avoid exposure to extreme heat or cold, and take precautions if you are prone to dehydration.
  • Consult your healthcare provider before starting any new medications or supplements, as they can interact with Nozinan.

Storage Instructions

  • Store Nozinan tablets at room temperature, between 59°F and 77°F (15°C and 25°C).
  • Keep the tablets in their original container, tightly closed to protect from moisture and light.
  • Avoid storing in areas with high humidity or direct sunlight.
  • Keep out of reach of children and pets.

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References

https://pdf.hres.ca/dpd_pm/00002959.PDF

Additional information

Brand Name:

Nozinan

Scientific Name:

Methotrimeprazine

Other Names:

Methoprazine

Strength(s):

2mg, 5mg, 25mg, 50mg

Quantities Available:

100

Formulation:

Tablet

The information above is provided by third parties to Prescriptionpoint.com for Nozinan (Methotrimeprazine). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.


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