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Nexgard (afoxolaner)

Indications

• Nexgard is prescribed to dogs to kill adult fleas and prevent flea infestations. It begins killing fleas within 30 minutes and provides protection for a full month.
• Nexgard is effective against various tick species, including black-legged ticks, American dog ticks, Lone Star ticks, and brown dog ticks. It helps to reduce the risk of diseases transmitted by these ticks.

Dosage and Administration

• Give Nexgard exactly as directed by your veterinarian, typically once a month.
• Administered the medication with or without food, based on your dog’s preference or your veterinarian’s advice.
• Make sure your dog chews the tablet completely before swallowing to ensure proper dosage delivery.
• Use the appropriate dosage based on your dog’s weight to ensure effectiveness and safety.
• Do not skip doses.
• Avoid using in cats as Nexgard is specifically formulated for dogs and should not be given to cats.
• Do not administer Nexgard to puppies less than 8 weeks of age or weighing less than 4 pounds.

Mechanism of Action

Nexgard (Afoxolaner) is an oral insecticide and acaricide that works by inhibiting the nervous system of fleas and ticks. Afoxolaner blocks ligand-gated chloride channels, particularly those gated by the neurotransmitter GABA, resulting in uncontrolled neuromuscular activity and death of the parasites. This mechanism provides effective control and prevention of flea and tick infestations.

Contraindications

• Known Hypersensitivity to Afoxolaner: Do not administer Nexgard if your dog has a known allergy to Afoxolaner or any of its components.
• Dogs with a History of Seizures: Use with caution in dogs with a history of seizures or neurologic disorders, as Nexgard may exacerbate these conditions.

Side Effects

Common Side Effects:

• Vomiting
• Dry or flaky skin
• Diarrhea
• Lethargy
• Loss of appetite

Serious Side Effects:

• Seizures
• Severe itching or rash
• Unusual behavior or changes in behavior
• Persistent vomiting or diarrhea

Precautions

• Monitor for Adverse Reactions: Watch your dog for any signs of adverse reactions, especially after the first administration, and contact your veterinarian if you observe any concerning symptoms.
• Inform About All Medications: Provide your veterinarian with a complete list of your dog’s current medications and supplements to avoid harmful interactions.
• Use in Breeding Dogs: Consult with your veterinarian before using Nexgard in breeding, pregnant, or lactating dogs.
• Avoid Use in Dogs with Uncontrolled Epilepsy: Use Nexgard with caution in dogs with a history of seizures or uncontrolled epilepsy.

Storage Instructions

• Keep Nexgard chewable tablets at 68°F to 77°F (20°C to 25°C).
• Store in the original blister pack to protect from moisture and light.
• Ensure that Nexgard is stored in a safe place away from children and other pets to prevent accidental ingestion.

References

https://nexgardforpets.com/sites/default/files/2023-07/NexGard_PLUS_PI_2023.pdf