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Motegrity (prucalopride)

Indications

Motegrity is indicated for the treatment of chronic idiopathic constipation (CIC) in adults, a condition characterized by infrequent bowel movements and difficulty passing stools.

Dosage and Administration

• Take Motegrity exactly as prescribed by your healthcare provider.
• Take the medication once daily, with or without food, preferably in the morning.
• Swallow the tablet whole with a full glass of water.
• Do not crush, chew, or break the tablet.
• Do not take an extra dose to make up for a missed one; take the next dose at the scheduled time.
• Avoid consuming grapefruit or grapefruit juice while taking Motegrity, as it may increase the levels of the medication in your bloodstream.

Mechanism of Action

Motegrity works by stimulating the motility of the gastrointestinal tract, specifically by activating serotonin receptors in the gut. This helps to increase the frequency and intensity of bowel movements, thereby relieving constipation.

Contraindications

• Gastrointestinal Obstruction: Do not take Motegrity if you have a known or suspected gastrointestinal obstruction, as it may exacerbate the condition.
• Severe Inflammatory Bowel Disease: It is contraindicated in patients with severe inflammatory bowel disease (such as Crohn’s disease or ulcerative colitis) due to the risk of worsening symptoms.
• Renal Impairment: Motegrity is not recommended for use in patients with severe renal impairment (creatinine clearance less than 30 mL/min).

Side Effects

Common Side Effects:

• Headache
• Nausea
• Abdominal pain

Serious Side Effects:

• Severe diarrhea
• Fainting or dizziness upon standing
• Suicidal thoughts or behavior (rare but serious)

Precautions

• Monitor Symptoms: Pay attention to any new or worsening symptoms, especially severe diarrhea or abdominal pain, and inform your doctor promptly.
• Driving and Operating Machinery: Motegrity may cause dizziness, so use caution when driving or operating machinery until you know how the medication affects you.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before taking Motegrity.

Storage Instructions

• Store Motegrity at room temperature away from moisture and heat.
• Keep the medication in its original container with the lid tightly closed to protect it from air and moisture.
• Store out of reach of children and pets to prevent accidental ingestion.

References

• https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210166s000lbl.pdf