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Midamor (amiloride)

Indications

• Midamor tablets are indicated for the treatment of high blood pressure (hypertension) and heart failure.
• It helps to prevent hypokalemia (low potassium levels) in patients taking diuretics that cause potassium loss.
• Used to manage edema (fluid retention) associated with congestive heart failure, liver cirrhosis, and certain kidney conditions.

Dosage and Administration

• Take Midamor tablets exactly as prescribed by your doctor, usually once daily with food to minimize gastrointestinal upset.
• Swallow the tablets whole with a full glass of water.
• Maintain a consistent schedule to ensure the best therapeutic effect.
• Follow your doctor’s instructions regarding dietary potassium and salt intake while taking Midamor.
• Do not exceed the prescribed dose of Midamor or take it more frequently than directed by your doctor.
• Avoid taking potassium supplements or potassium-containing salt substitutes unless instructed by your doctor.
• Do not stop taking Midamor abruptly without consulting your doctor, as it may worsen your condition.
• Do not share your medication with others, even if they have similar symptoms.

Mechanism of Action

Midamor contains Amiloride, a potassium-sparing diuretic. It works by inhibiting sodium reabsorption in the kidneys, which helps to excrete excess fluid from the body while retaining potassium, thus maintaining a proper electrolyte balance.

Contraindications

• Do not use Midamor if you have a known allergy to Amiloride or any other ingredients in the tablets.
• Avoid Midamor if you have hyperkalemia (high potassium levels), kidney impairment, or anuria (inability to produce urine).
• Consult your doctor before using Midamor if you have existing medical conditions, particularly diabetes, liver disease, or electrolyte imbalances.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness
• Abdominal pain

Serious Side Effects:

• Signs of high potassium levels (muscle weakness, slow or irregular heartbeat)
• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Kidney problems (changes in urine output, swelling in the legs or ankles)
• Severe dehydration or electrolyte imbalances
• Signs of infection (fever, sore throat, chills)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Midamor.
• Monitor your potassium levels regularly to avoid hyperkalemia, especially if you are also taking other medications that affect potassium levels.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Midamor with your healthcare provider.

Storage Instructions

• Store Midamor tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original packaging until they are ready to use.
• Do not use Midamor if the tablets appear discolored, damaged, or show signs of deterioration.

References

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/18-200S024_Midamor_Prntlbl.pdf