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Mexitil (mexiletine)

Indications

• Mexitil capsules are indicated for the treatment of life-threatening ventricular arrhythmias, such as sustained ventricular tachycardia.
• It helps to restore normal heart rhythm and maintain a regular, steady heartbeat.

Dosage and Administration

• Take Mexitil capsules exactly as prescribed by your doctor, usually every 8 to 12 hours.
• Swallow the capsules whole with a full glass of water.
• Take Mexitil with food or an antacid to minimize gastrointestinal discomfort.
• Follow your doctor’s instructions carefully regarding the timing and dosing of Mexitil to achieve the best therapeutic effect.
• Take a missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule.
• Do not exceed the prescribed dose of Mexitil or take it more frequently than directed by your doctor.
• Avoid stopping Mexitil abruptly without consulting your doctor, as it may worsen your heart condition.
• Do not share your medication with others, even if they have similar symptoms.

Mechanism of Action

Mexitil contains Mexiletine, an antiarrhythmic medication that works by blocking sodium channels in the heart. This action stabilizes the heart’s electrical activity, reducing abnormal heart rhythms and helping to restore a normal heartbeat.

Contraindications

• Do not use Mexitil if you have a known allergy to Mexiletine or any other ingredients in the capsules.
• Avoid taking the medication if you have cardiogenic shock, second- or third-degree heart block (without a pacemaker), or severe liver disease.
• Consult your doctor before using Mexitil if you have existing medical conditions, particularly liver or kidney problems, or a history of heart conditions.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Heartburn
• Dizziness
• Tremor
• Coordination problems

Serious Side Effects:

• Severe dizziness or fainting
• Worsening of heart rhythm problems
• Liver problems (yellowing of the skin or eyes, dark urine, severe fatigue)
• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Signs of infection (fever, chills, sore throat)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Mexitil.
• Be cautious if you have a history of liver or kidney problems, as dose adjustments may be necessary.
• Monitor for signs of worsening heart rhythm problems or severe dizziness, and report these symptoms to your doctor immediately.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Mexitil with your healthcare provider.

Storage Instructions

• Store Mexitil capsules at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the capsules in their original packaging until ready to use.
• Do not use Mexitil if the capsules appear discolored, damaged, or show signs of deterioration.
• Dispose of any unused or expired medication properly, following local regulations or guidelines.

References

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ab73778b-6794-441c-b127-610a6d0733ea