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Mevacor (lovastatin)

Indications

• Mevacor tablets are indicated for the treatment of high cholesterol (hypercholesterolemia) to reduce the risk of heart disease and stroke.
• It helps to lower levels of “bad” cholesterol (LDL) and triglycerides in the blood while raising levels of “good” cholesterol (HDL).

Dosage and Administration

• Take Mevacor tablets exactly as prescribed by your doctor, usually once daily with the evening meal.
• Swallow the tablets whole with a full glass of water.
• Maintain a consistent diet low in cholesterol and fat to enhance the effectiveness of Mevacor.
• Attend regular follow-up appointments with your doctor to monitor your cholesterol levels and adjust the dose if necessary.
• Take a missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule.
• Do not exceed the prescribed dose of Mevacor or take it more frequently than directed by your doctor.
• Avoid drinking large quantities of grapefruit juice while taking Mevacor, as it can increase the medication levels in your blood and lead to adverse effects.
• Do not stop taking Mevacor abruptly without consulting your doctor, as it may cause your cholesterol levels to increase.
• Do not share your medication with others, even if they have similar symptoms.

Mechanism of Action

Mevacor contains Lovastatin, which belongs to a class of drugs known as statins. It works by inhibiting an enzyme (HMG-CoA reductase) involved in the production of cholesterol in the liver. This action helps to reduce the levels of cholesterol and other fatty substances in the blood.

Contraindications

• Do not use Mevacor if you have a known allergy to Lovastatin or any other ingredients in the tablets.
• Avoid Mevacor if you have active liver disease or unexplained persistent elevations of liver enzymes.
• Consult your doctor before using Mevacor if you have existing medical conditions, particularly liver or kidney problems.

Side Effects

Common Side Effects:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Muscle pain or weakness

Serious Side Effects:

• Severe muscle problems (rhabdomyolysis) leading to kidney damage
• Liver problems (yellowing of the skin or eyes, dark urine, severe fatigue)
• Severe allergic reactions (rash, itching, swelling, difficulty breathing)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Mevacor.
• Be cautious if you have a history of liver problems, as liver function tests may be required.
• Monitor for signs of muscle pain, tenderness, or weakness, especially if accompanied by fever or malaise, and report these symptoms to your doctor immediately.
• If you are pregnant, planning to become pregnant, or breastfeeding, do not use Mevacor, as it can harm the fetus or nursing baby.

Storage Instructions

• Store Mevacor tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original packaging until they are ready to use.
• Do not use Mevacor if the tablets appear discolored, damaged, or show signs of deterioration.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019643s085lbl.pdf