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Metrogel (metronidazole)

Indications

• Bacterial Vaginosis: You can use Metrogel to treat bacterial vaginosis, helping to restore the natural balance of bacteria in your vagina and reduce symptoms such as discharge, odor, and discomfort.
• Trichomoniasis: Your doctor may prescribe Metrogel to treat trichomoniasis, a sexually transmitted infection caused by the parasite Trichomonas vaginalis, helping to eliminate the infection and alleviate symptoms.
• Amebiasis: Metrogel is used to treat amebiasis, an intestinal infection caused by the amoeba Entamoeba histolytica, helping to clear the infection and reduce symptoms like diarrhea and abdominal pain.
• Anaerobic Bacterial Infections: You can use Metrogel to treat infections caused by anaerobic bacteria, such as intra-abdominal infections, skin infections, and bone and joint infections, helping to eliminate the bacteria and promote recovery.

Dosage and Administration

• Take Metrogel exactly as prescribed by your doctor.
• Swallow the tablets whole with a full glass of water.
• Take it with food to reduce stomach upset.
• Complete the full course of the medication, even if you start feeling better, to ensure the infection is fully cleared.
• Inform your doctor about any other medications or supplements you are taking.
• Do not crush, chew, or break the tablets.
• Avoid alcohol while taking Metrogel and for at least 48 hours after finishing the course, as it can cause a severe reaction with symptoms like nausea, vomiting, and headache.
• Do not skip doses; take it as soon as you remember if you miss a dose, but do not double dose to make up for a missed one.
• Do not stop taking Metrogel without consulting your doctor, even if you feel better.

Mechanism of Action

Metrogel works by entering the cells of anaerobic bacteria and protozoa. Once inside, it disrupts their DNA, inhibiting nucleic acid synthesis. This action leads to the death of the bacteria or protozoa, thereby eliminating the infection and alleviating associated symptoms.

Contraindications

• Do not use Metrogel if you are allergic to metronidazole or any of its ingredients.
• Avoid using this medication if you are in the first trimester of pregnancy unless your doctor advises it.
• Do not use Metrogel if you have a history of blood disorders, such as leukopenia.
• Avoid using this medication if you have a severe liver condition.
• Do not take Metrogel if you are currently taking disulfiram or have used it in the past two weeks.

Side Effects

Common Side Effects

• Nausea
• Headache
• Loss of appetite
• Metallic taste in the mouth
• Diarrhea

Serious Side Effects

• Severe abdominal pain or persistent diarrhea
• Signs of a severe allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)
• Seizures
• Numbness or tingling in the hands or feet
• Severe headache or vision changes

Precautions

• Inform your doctor about any existing health conditions, especially liver disease or blood disorders.
• Regularly monitor your blood counts if you are on a prolonged course of Metrogel.
• Avoid alcohol during treatment and for at least 48 hours after completing the course to prevent adverse reactions.
• Use effective contraception during treatment if you are of childbearing age and consult your doctor if you are pregnant or planning to become pregnant.
• Discuss all other medications you are taking with your doctor to avoid potential interactions.
• If you experience any unusual symptoms, such as numbness or tingling in your extremities, inform your doctor immediately.

Storage Instructions

• Store Metrogel at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original container, tightly closed.
• Protect from moisture and light.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the label.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021789s003lbl.pdf