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Lotrel (amlodipine besylate and benazepril hydrochloride)

Indications

Lotrel is used to treat high blood pressure, reducing the risk of strokes, heart attacks, and kidney problems.

Dosage and Administration

• Take Lotrel exactly as prescribed by your healthcare provider.
• Take the capsule at the same time each day to maintain an even level in your blood.
• Lotrel can be taken with or without food but try to take it the same way each day.
• Take the capsule whole with a full glass of water; do not crush or chew.
• Do not consume grapefruit or grapefruit juice while taking Lotrel, as it can increase the risk of side effects.
• Do not stop taking Lotrel suddenly without consulting your doctor, as this can worsen your condition.

Mechanism of Action

Lotrel combines two medications: amlodipine, a calcium channel blocker, and benazepril, an angiotensin-converting enzyme (ACE) inhibitor. Amlodipine works by relaxing the blood vessels so that blood can flow more easily, while benazepril decreases certain chemicals that tighten the blood vessels, further helping to relax them and lower blood pressure.

Contraindications

• Allergy to Amlodipine or Benazepril: Do not use the medication if you have a known allergy to either medication or any other ingredients in the capsule.
• History of Angioedema: Avoid if you have a history of angioedema (swelling of the face, lips, tongue, or throat) related to previous ACE inhibitor treatment.
• Pregnancy: Contraindicated during pregnancy due to the risk of harm to the unborn baby.
• Severe Kidney Disease: Not recommended for patients with severe renal impairment without close monitoring.

Side Effects

Common Side Effects:

• Dizziness
• Cough
• Swelling of the legs or ankles (edema)
• Headache
• Fatigue
• Nausea

Serious Side Effects:

• Severe dizziness or fainting
• Swelling of the hands, feet, or ankles
• Irregular heartbeat
• Signs of kidney problems (such as a change in the amount of urine)
• Signs of a high potassium blood level (muscle weakness, slow/irregular heartbeat)
• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)

Precautions

• Monitor Blood Pressure: Regularly check your blood pressure to ensure the medication is effectively managing your condition.
• Inform About Other Medications: Tell your doctor about all other medications you are taking to avoid potential interactions.
• Diabetes: Inform your doctor if you have diabetes, as Lotrel can affect blood sugar levels.

Storage Instructions

• Store Lotrel at room temperature between 20°C to 25°C (68°F to 77°F).
• Store in a dry place, away from moisture and light.
• Keep the capsules in their original container with the cap tightly closed when not in use.
• Ensure the medication is stored safely away from children.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020364s065lbl.pdf