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Keppra (levetiracetam) 

Indications

Keppra is indicated in the treatment of: 

• It helps with seizures that start in one part of the brain and can affect both children and adults. 
• It’s also used for a specific type of seizure called myoclonic seizures, which often happen in teenagers. 
• Keppra can also be used for a certain kind of severe seizure that affects both sides of the brain and usually starts in childhood or adolescence. 

Dosage and Administration

• Take Keppra as directed by your healthcare provider, usually twice daily with or without food. 
• Take the medication regularly at the same time each day to maximize its benefits. 
• Follow all directions on your prescription label and read all medication guides or instruction sheets. 
• Do not increase the dose or use the medication more frequently or for longer than prescribed. 
• Do not crush or chew the tablets. 
• Do not stop taking Keppra without consulting your healthcare provider, as abrupt discontinuation may worsen seizures. 

Mechanism of Action

Keppra works in a way that’s not completely clear yet, but it is believed to help control seizures by changing how certain chemicals are released in the brain. One idea is that it stops calcium from flowing through certain channels in the brain, which might help reduce the chance of seizures happening. 

Contraindications

Keppra is contraindicated in individuals with known hypersensitivity to levetiracetam. 

Side Effects

Common Side Effects: 

• Dizziness 
• Drowsiness 
• Tiredness 
• Weakness 
• Irritability or aggressiveness 
• Loss of appetite 
• Stuffy nose 
• Infection 
• Behavioral abnormalities in young children 
• Psychotic symptoms in young children 
• Increased blood pressure in children aged 1 month to 4 years 
• Decreased appetite 
• Increased blood pressure 
• Nasal congestion 
• Sleepiness 
• Headache, especially in children 

Serious Side Effects: 

• Suicidal thoughts or behavior 
• Unusual mood or behavior changes 
• Severe injuries due to dizziness or drowsiness 

Precautions

• Keep an eye out for any unusual behavior like feeling paranoid, thinking about harming oneself, being overly irritable, or acting aggressively. If you notice these signs, talk to your doctor. 
• Watch out for any signs of feeling down or having thoughts of hurting yourself, and let your doctor know if you start feeling unusually moody or behave differently. 
• Be careful if you feel sleepy or tired while taking Keppra, and don’t drive or use heavy machinery until you’re used to how the medication affects you. 
• If you need to stop taking Keppra, do it gradually with your doctor’s guidance to avoid having seizures come back. 

Storage Instructions

Store Keppra at room temperature, around 25°C (77°F), with excursions permitted between 15°C to 30°C (59°F to 86°F). 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021035s099,021505s038lbl.pdf