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Drug Name Dosage Quantity Price Buy Now
Glyxambi 10/5mg 90 $420.00 Add To Cart
Glyxambi 25/5mg 90 $510.00 Add To Cart
Dosage: 10/5mg
Quantity: 90
Price: $420.00
Dosage: 25/5mg
Quantity: 90
Price: $510.00

What is Glyxambi used for?

Glyxambi is a brand-name medication that can only be obtained with a doctor’s prescription. It is used along with proper diet and adequate exercise for treating adult patients with type 2 diabetes mellitus. 

It is also used in adults who have type2 diabetes and heart disease to lower the risk of death from stroke, heart failure, or heart attack.

Glyxambi drug class

Glyxambi is classified as an antidiabetic combination that contains two medicines for diabetes, empagliflozin (Jardiance) and linagliptin (Tradjenta).

Empagliflozin (Jardiance) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor that works by blocking the action of SGLT2, which is responsible for the reabsorption of glucose from the kidneys back into circulation. Blocking SGLT2 by empagliflozin reduces the reabsorption of glucose in the kidneys and removes excess glucose into the urine, thus reducing glucose levels in the blood.

Linagliptin (Tradjenta) is a dipeptidyl-peptidase-4 (DPP-4) inhibitor that blocks the breakdown of incretin, hormones released after consuming food and stimulates the pancreas to produce insulin when blood glucose levels are high. Linagliptin also stimulates the liver to make less glucose.

Glyxambi dosage

Glyxambi (empagliflozin and linagliptin) comes in tablet form and is available in two different strengths: 

Glyxambi 10 mg (empagliflozin)/5 mg (linagliptin) 

Glyxambi 25 mg (empagliflozin)/5 mg (linagliptin)

For adults with type 2 diabetes, the recommended dose of Glyxambi is 10 mg (empagliflozin)/5 mg (linagliptin) once a day in the morning. For patients who can tolerate this medication, the dose may be increased to 25 mg (empagliflozin)/5 mg (linagliptin) once a day for additional blood sugar control. 

Glyxambi is not recommended for use in patients who have an EGFR below 30 mL/min/1.73 m2. 

Before starting Glyxambi treatment, renal function should be assessed as clinically indicated.  

For patients who have volume depletion, correcting it is a must before starting Glyxambi treatment.


Take Glyxambi exactly as prescribed by your physician. Read all the medication guides and instruction sheets and carefully follow all the instructions on the prescription label.

This medication is usually taken on an empty or full stomach in the morning.

Your blood sugar should be checked regularly and you may also have to test the level of ketones in your urine.


Do not take Glyxambi if you are allergic to it or to any of its active and inactive ingredients.

Do not take this medication if you have severe kidney disease or undergo dialysis treatment.

Before you start taking this drug, inform your doctor about all your medical conditions, especially kidney or liver problems, previous infection of the vagina and penis, a history of urination problems or urinary tract infection (UTI), if you will undergo surgery, changes in your diet or eating less, previous or present problems with your pancreas such as pancreatitis or surgery on your pancreas, drinking too much alcohol, type 1 diabetes, pregnant or planning to be one, and breastfeeding or planning to do so.

Inform your doctor about all the medications you take, including non-prescription/over-the-counter and prescription medications, vitamins, supplements, and herbal products. Other medications may affect Glyxambi and vice versa.

Glyxambi side effects

Like most medications, Glyxambi may cause some unwanted side effects. Some may go away after the body has adjusted to the drug, but some may need immediate medical attention.

Here are the common side effects reported while on Glyxambi: 

Urinary tract infections 

Stuffy or runny nose and sore throat (Cold-like symptoms) 

Upper respiratory tract infections

Some serious adverse reactions to the use of Glyxambi: 

A feeling like you might pass out (lightheadedness) 

Joint pain that is severe or ongoing 

Serious skin reactions are shown by itching, blisters, breakdown of the outer layer of the skin 

Ketoacidosis (high levels of acid in the blood) is shown by nausea and vomiting, stomach pain, trouble breathing, or unusual sleepiness. 

Pancreatitis is shown by nausea and vomiting, and severe pain in the upper part of the stomach that spreads to the back. 

Dehydration is shown by confusion, dizziness, a very thirsty feeling, and less urination 

Bladder infection is shown by a burning feeling or pain when urinating, blood in the urine, and pelvic or back pain. 

Heart failure symptoms include shortness of breath, swelling of the legs or feet, and rapid weight gain.

Glyxambi weight loss

Glyxambi is not approved as a weight loss medication, however, it may cause some people to lose 3% of their body weight on average. It led to more weight loss than using linagliptin alone.

How much does Glyxambi cost in Canada? 

Glyxambi price can be very expensive. But with its effectiveness, the price is reasonable. 

Check the top of this description to see our prices.

Frequently asked questions about Glyxambi

Can Glyxambi and metformin be taken together? 

Yes, they can be given together to people with type 2 diabetes who need additional control to reduce blood sugar levels.

What happens if I overdose on Glyxambi? 

You will experience hypoglycemia (Low blood sugar levels), characterized by tremors, sweating, weakness, confusion, fast heart, trouble speaking, nausea and vomiting, rapid breathing, fainting, and seizure. If this happens, get medical help immediately or call the poison helpline.

When is the best time to take Glyxambi? 

Glyxambi is typically taken in the morning, either with or without food. There is a risk of life-threatening ketoacidosis (high blood acidity) associated with empagliflozin. Check your blood sugar frequently, and you may also need to test your urine for ketones. 

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10/5mg, 25/5mg

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The information above is provided by third parties to for Glyxambi (Empagliflozin/Linagliptin). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.