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Depakote (divalproex) 


Depakote is an anti-epileptic drug indicated for: 

  • Treatment of manic episodes associated with bipolar disorder 
  • Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures 
  • Prophylaxis of migraine headaches 

Dosage and Administration

  • Take Depakote orally in divided doses as prescribed by a healthcare professional. 
  • Swallow Depakote tablets whole. 
  • Start with an initial dose of 750 mg daily for mania. 
  • Increase the dose as rapidly as possible to achieve the therapeutic response or desired plasma level for mania. 
  • Begin with a dosage of 10 to 15 mg/kg/day for complex partial seizures. 
  • Increase the dosage at 1-week intervals by 5 to 10 mg/kg/day for complex partial seizures. 
  • Monitor for optimal clinical response for complex partial seizures. 
  • Start with a dosage of 15 mg/kg/day for absence seizures. 
  • Increase the dosage at 1-week intervals by 5 to 10 mg/kg/day for absence seizures. 
  • Adjust dosage based on seizure control and side effects for absence seizures. 
  • Begin with a recommended starting dose of 250 mg twice daily for migraine. 
  • Increase dosage as needed, with a maximum of 1,000 mg/day for migraine. 
  • Always consult with a healthcare provider for personalized dosing instructions and adjustments. 
  • Don’t crush or chew Depakote tablets. 
  • Don’t exceed the maximum recommended dosage without consulting a healthcare provider. 
  • Don’t adjust the dosage or frequency of Depakote without consulting a healthcare provider. 
  • Don’t discontinue Depakote abruptly without medical advice, as it may lead to withdrawal symptoms or worsening of the condition. 
  • Don’t use Depakote for conditions other than those prescribed by a healthcare provider. 

Mechanism of Action

Depakote’s mechanism of action is not fully understood but is thought to involve increased brain levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. 


  • Hepatic disease or significant hepatic dysfunction 
  • Known mitochondrial disorders caused by mutations in mitochondrial DNA polymerase γ (POLG) 
  • Suspected POLG-related disorder in children under two years of age 
  • Known hypersensitivity to the drug 
  • Urea cycle disorders 

Side Effects

Common side effects: 

  • Nausea 
  • Vomiting 
  • Stomach pain 
  • Diarrhea 
  • Constipation 
  • Dizziness 
  • Drowsiness 
  • Weakness 
  • Tremors 
  • Memory problems 
  • Loss of appetite 
  • Gastrointestinal (GI) side effects such as indigestion 
  • Loss of appetite 
  • Abdominal pain. 
  • Partial tablets in stool, which may occur in certain intestinal disorders 

Serious side effects: 

  • Low platelet count 
  • Hypothermia 
  • High levels of ammonia in the blood 
  • Depression 
  • Suicidal thoughts or behaviors 
  • Risk of liver damage 
  • Pancreatitis 
  • Fetal harm 
  • Severe allergic reactions 
  • Bleeding problems 
  • Chest pain 
  • Easy bruising/unexplained bleeding 
  • Fast/slow/irregular heartbeat 
  • Swelling of hands/feet  
  • Uncontrolled eye movement (nystagmus) 
  • Feeling cold/shivering 
  • Rapid breathing 
  • Loss of consciousness 


  • If you’re at a high risk for liver problems, your doctor will monitor your liver function with blood tests while you’re taking Depakote. 
  • Pregnant women or those who could become pregnant should avoid using Depakote unless there are no other options, as it can cause birth defects and neurodevelopmental disorders in babies. 
  • If you develop pancreatitis while taking Depakote, your doctor will likely stop the medication. 
  • If you experience suicidal thoughts or behavior while taking Depakote, let your doctor know right away, as this medication can increase the risk. 
  • Your doctor may monitor your platelet counts and coagulation tests if you’re at risk of bleeding or other blood disorders while taking Depakote. 
  • If you feel unusually tired, vomit, or experience changes in mental status while taking Depakote, especially if you’re also taking topiramate, your doctor may check your ammonia levels and consider stopping Depakote. 
  • Be aware that Depakote may cause hypothermia, especially when taken with topiramate. 
  • If you develop a severe allergic reaction like DRESS while taking Depakote, stop the medication immediately. 
  • If you’re elderly and experience drowsiness while taking Depakote, your doctor may adjust your dosage slowly and monitor your fluid and nutritional intake closely. 

Storage Instructions

Store tablets below 86°F (30°C). 


How can I buy Depakote online from

To buy Depakote online from, simply navigate to the product page for the specific Depakote dosage you need. From there, select the desired quantity and dosage strength, and click on the “Add to Cart” button. Proceed to checkout and follow the prompts to complete your purchase securely.

How soon will my Depakote order be shipped, and how long will it take to arrive?

Please allow 2-4 weeks for delivery of your Depakote.

What is your return/refund policy?

We want you to be completely satisfied with your purchase of Depakote. Because we work in conjunction with licensed pharmacies to protect the safety of you and other parties involved, once a prescription and non-prescription products have been dispensed it cannot be returned for any reason. Under the pharmaceutical law, prescription drugs are not returnable. All sales are final. So before ordering (completing your order) please consult with your physician regarding your medications.

What payment methods does accept? accepts various payment methods for you to buy Depakote conveniently. We accept payments through Personal Checks, International Money Orders, and Certified Checks. In addition, we will also accept E-checks.

Insurance does not directly interact with any type of insurance payment. Some insurance companies will reimburse the consumer for medications purchased out of pocket. Check with your benefits provider for more details.

Do I have to order by credit card?

No. Although paying by credit card is the most convenient payment method, some patients do pay by money order. It should be noted that as a security measure, does not keep your credit card information on file. This information is deleted from our system after every transaction.



Additional information

Brand Name:


Scientific Name:


Other Names:

Depakote, Divalproex, Epival


125mg, 250mg, 500mg

Quantities Available:

90, 100


Delayed Release Tablet, Delayed Release Tablet (Enteric Coated)

The information above is provided by third parties to for Depakote (Divalproex). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.