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Colestid (colestipol)

Indications

• Colestid tablets are indicated for the treatment of primary hypercholesterolemia (high cholesterol) in patients who do not adequately respond to diet and exercise alone.
• It is used to lower cholesterol levels and reduce the risk of cardiovascular disease.

Dosage and Administration

• Take Colestid tablets exactly as prescribed by your doctor, typically one to four times daily.
• Swallow the tablets whole with a full glass of water.
• Take the medication with meals to enhance its effectiveness and reduce the risk of gastrointestinal side effects.
• Follow your doctor’s instructions regarding the appropriate dosage and frequency of Colestid use.
• Do not exceed the prescribed dose of Colestid or take it more frequently than directed by your doctor.
• Do not crush, chew, or break the tablets.
• Avoid taking other medications simultaneously with Colestid; take them at least 1 hour before or 4 hours after taking Colestid to prevent interactions.
• Do not stop taking Colestid abruptly without consulting your doctor, as it may affect your cholesterol levels.

Mechanism of Action

Colestid contains Colestipol, a bile acid sequestrant. It works by binding bile acids in the intestine, preventing their reabsorption. This process lowers cholesterol levels in the blood by increasing the conversion of cholesterol to bile acids in the liver.

Contraindications

• Do not use Colestid if you have a known allergy to Colestipol or any other ingredients in the tablets.
• Avoid Colestid if you have a history of complete biliary obstruction.
• Consult your doctor before using the medication if you have existing medical conditions, particularly gastrointestinal disorders.

Side Effects

Common Side Effects:

• Constipation
• Stomach pain or discomfort
• Nausea
• Indigestion
• Bloating or gas

Serious Side Effects:

• Severe constipation or abdominal pain
• Signs of bowel obstruction (severe stomach pain, vomiting, inability to pass gas or stool)
• Unusual bleeding or bruising
• Severe allergic reactions (rash, itching, swelling, difficulty breathing)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Colestid.
• Be cautious when taking other medications; ensure there is an appropriate interval between Colestid and other drugs to avoid interactions.
• Increase your intake of dietary fiber and fluids to help manage constipation while taking Colestid.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Colestid with your healthcare provider.

Storage Instructions

• Store Colestid tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original packaging until they are ready to use.
• Keep Colestid out of reach of children and pets.
• Do not use Colestid if the tablets appear discolored, damaged, or show signs of deterioration.

References

https://www.accessdata.fda.gov/spl/data/4378d85f-6a69-46bb-85d7-2e69fd41c293/4378d85f-6a69-46bb-85d7-2e69fd41c293.xml