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Chantix (varenicline) 

Indications

Chantix is used to help people stop smoking by reducing cravings and withdrawal symptoms. 

Dosage and Administration

• Start Chantix dosing one week before your planned quit date. 
• Begin Chantix dosing and quit smoking between days 8 and 35 of treatment, as an alternative. 
• Take Chantix after eating and with a full glass of water. 
• Follow the treatment for 12 weeks. 
• Continue with an additional 12-week course if you successfully stop smoking after the initial 12 weeks to increase the chances of long-term abstinence. 
• Attempt another quit if you do not stop smoking within the initial 12 weeks or if you relapse, after identifying and addressing contributing factors. 
• Discuss with your doctor about temporarily or permanently reducing the dose if you cannot tolerate the side effects. 
• Do not skip doses. 
• Do not stop taking Chantix without consulting your healthcare provider. 
• Do not take Chantix on an empty stomach. 
• Do not ignore the side effects; report them to your doctor. 

Mechanism of Action

Chantix works by partially stimulating nicotine receptors in the brain. This helps reduce cravings and withdrawal symptoms associated with quitting smoking while also blocking the pleasurable effects of nicotine from cigarettes. 

Contraindications

Do not use the medication if you have a history of serious hypersensitivity or skin reactions to Chantix. 

Side Effects

Common Side Effects: 

• Nausea 
• Headache 
• Insomnia 
• Abnormal dreams 
• Constipation 

Serious Side Effects: 

• Serious skin reactions 
• Angioedema (swelling beneath the skin) 
• Cardiovascular events (e.g., heart attack) 
• Depression and suicidal thoughts 

Precautions 

• Angioedema and Hypersensitivity Reactions: Discontinue Chantix and seek medical care immediately if symptoms occur.
• Serious Skin Reactions: Discontinue Chantix and contact a healthcare provider immediately if a skin rash with mucosal lesions appears.
• Cardiovascular Events: If you have stable cardiovascular disease, report new or worsening cardiovascular symptoms and seek immediate medical attention if you experience signs and symptoms of a heart attack.
• Accidental Injury: Use caution when driving or operating machinery until you know how Chantix affects you, as accidental injuries have been reported.

Storage Instructions

Store Chantix at room temperature, between 59 to 86°F (15 to 30°C). 

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021928s025lbl.pdf