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Brilinta (ticagrelor)

Indications

• Use Brilinta to reduce the risk of heart attack, stroke, and cardiovascular death in patients with acute coronary syndrome (ACS) or a history of myocardial infarction (heart attack).
• You can use it to prevent blood clots in patients with coronary artery disease who have undergone stent placement or other heart procedures.
• It helps maintain open blood vessels and improve blood flow in individuals with a history of cardiovascular events.

Dosage and Administration

• Take Brilinta exactly as prescribed by your doctor, typically twice daily.
• Swallow the tablet whole with a full glass of water.
• You can take Brilinta with or without food.
• Follow your doctor’s instructions regarding the concurrent use of low-dose aspirin (usually 75-100 mg daily) while taking Brilinta.
• Do not exceed the prescribed dose; taking more can increase the risk of severe bleeding.
• Avoid stopping Brilinta suddenly without consulting your doctor, as this can increase the risk of a heart attack or stroke.
• Do not take Brilinta if you are taking more than 100 mg of aspirin daily, as higher doses can reduce its effectiveness.
• Avoid drinking alcohol excessively, as it can increase the risk of stomach bleeding.

Mechanism of Action

Brilinta is an antiplatelet medication that works by inhibiting the P2Y12 ADP receptor on platelets. This prevents platelets from sticking together and forming clots, thereby improving blood flow and reducing the risk of heart attack and stroke in individuals with cardiovascular disease.

Contraindications

• Do not use Brilinta if you are allergic to ticagrelor or any other ingredients in the medication.
• Avoid taking Brilinta if you have active bleeding, such as peptic ulcers or a history of intracranial hemorrhage.
• Do not use it if you have severe liver disease.

Side Effects

Common Side Effects

• Shortness of breath
• Easy bruising
• Mild nosebleed
• Headache
• Dizziness

Serious Side Effects

• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing)
• Major bleeding (uncontrolled bleeding, blood in urine, black or bloody stools)
• Irregular heartbeat
• Fainting or feeling lightheaded
• Signs of liver problems (yellowing of the skin or eyes, dark urine, severe stomach/abdominal pain)

Precautions

• Inform your doctor if you have a history of bleeding problems, gout, or asthma before taking Brilinta.
• You should avoid activities that may increase your risk of bleeding or injury while on Brilinta.
• Monitor for signs of bleeding and report any unusual bleeding or bruising to your doctor immediately.
• Discuss with your doctor if you are planning to become pregnant, are pregnant, or are breastfeeding before starting Brilinta.
• Regularly attend follow-up appointments to monitor your condition and response to the medication.

Storage Instructions

• Store Brilinta at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the medication away from light and moisture.
• Do not store it in the bathroom.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/022433s020lbl.pdf