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Avalide (irbesartan and hydrochlorothiazide)

Indications

• Avalide is used to treat high blood pressure (hypertension).
• It helps lower blood pressure to reduce the risk of strokes, heart attacks, and kidney problems.

Dosage and Administration

• Take Avalide exactly as prescribed by your doctor, usually once daily.
• Swallow the tablets whole with a glass of water, preferably in the morning to avoid nighttime urination.
• Continue taking Avalide even if you feel well, as high blood pressure often has no symptoms.
• Do not skip doses or stop taking Avalide without consulting your doctor.
• Avoid taking Avalide with alcohol, as it can increase the risk of side effects such as dizziness.
• Avoid taking potassium supplements or salt substitutes containing potassium without your doctor’s approval.

Mechanism of Action

Avalide contains two active ingredients: irbesartan and hydrochlorothiazide. Irbesartan is an angiotensin II receptor blocker (ARB) that relaxes blood vessels by blocking the action of a natural substance that tightens blood vessels. Hydrochlorothiazide is a diuretic (water pill) that helps your body get rid of excess salt and water by increasing urine output. Together, they help lower blood pressure more effectively than either drug alone.

Contraindications

• Do not use Avalide if you are allergic to irbesartan, hydrochlorothiazide, or any of the inactive ingredients.
• Avoid Avalide if you are pregnant, planning to become pregnant, or breastfeeding, as it can harm the baby.
• Do not take Avalide if you have severe kidney disease or are unable to urinate.
• Avoid using Avalide if you have a history of severe allergic reactions to sulfa drugs.
• Do not take Avalide if you have severe liver disease, or a condition called anuria (no urine production).

Side Effects

Common Side Effects

• Dizziness or lightheadedness
• Fatigue
• Nausea
• Muscle cramps
• Increased urination

Serious Side Effects

• Severe allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing
• Signs of high potassium levels, such as muscle weakness, slow or irregular heartbeat
• Signs of kidney problems, such as changes in urine output
• Severe dehydration and electrolyte imbalances
• Severe or persistent vomiting and diarrhea

Precautions

• Inform your doctor about your complete medical history, especially if you have kidney disease, liver disease, or gout.
• Notify your doctor if you have diabetes, as Avalide may affect your blood sugar levels.
• Use caution if you are elderly, as you may be more sensitive to the effects of the medication, particularly dizziness and changes in potassium levels.
• Be aware of signs of dehydration, such as extreme thirst or dry mouth, and inform your doctor if these occur.
• Monitor your blood pressure regularly and report any significant changes to your doctor.
• Avoid prolonged exposure to sunlight or tanning booths, as Avalide can make your skin more sensitive to the sun.

Storage Instructions

• Store Avalide at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original container, tightly closed.
• Store Avalide out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020758s059lbl.pdf