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Bactroban ointment (mupirocin)

Indications

• Use Bactroban Ointment to treat various skin infections such as impetigo, folliculitis, and furunculosis. You will find it effectively combats the bacteria causing these conditions.
• You can use it to treat secondary skin infections like infected dermatitis and infected eczema.
• Eliminate nasal carriage of Staphylococcus aureus with Bactroban, helping you reduce the risk of spreading infection.

Dosage and Administration

• Clean the affected area gently and dry it before applying the ointment.
• Apply a small amount, typically a thin layer, to cover the infected area.
• Use the ointment regularly, applying it 2-3 times a day as directed by your healthcare provider. You may cover the treated area with a sterile gauze bandage if advised by your doctor.
• Ensure the ointment does not come into contact with your eyes, nose (unless treating nasal infections), or mouth.
• Maintain the application schedule and complete the full course even if symptoms improve.
• Do not use larger amounts or apply more often than prescribed.
• Avoid prolonged use to prevent resistance; use only as directed by your healthcare provider.

Mechanism of Action

Bactroban Ointment contains mupirocin, an antibiotic that inhibits bacterial protein synthesis by binding to bacterial isoleucyl-tRNA synthetase. This prevents the bacteria from producing essential proteins needed for their growth and replication, ultimately leading to death.

Contraindications

• Do not use it if you are allergic to mupirocin or any of the ingredients in Bactroban Ointment.
• Avoid use if you have severe kidney disease, as absorption of polyethylene glycol, the ointment base, can occur.
• Do not apply to large areas of damaged skin, especially if you have moderate or severe renal impairment.

Side Effects

Common Side Effects

• Mild burning or stinging sensation at the application site.
• Itching at the application site.
• Dryness or flakiness of the treated area.

Serious Side Effects

• Severe allergic reactions such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
• Prolonged use can lead to superinfection with resistant bacteria or fungi.

Precautions

• Consult your doctor if you are pregnant or breastfeeding before using Bactroban.
• You should use the ointment only on the skin and as prescribed.
• You must watch for new signs of infection, which might indicate a superinfection.
• Do not mix with other topical antibiotics unless advised by your healthcare provider.

Storage Instructions

• Store Bactroban Ointment at room temperature, ideally between 20°C to 25°C (68°F to 77°F).
• Do not store in high humidity or temperatures above 30°C (86°F).
• Keep the ointment in a secure place away from children and pets.
• Do not freeze the ointment, as freezing can alter its effectiveness.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050591s034lbl.pdf