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Nolvadex (tamoxifen)

Indications

• Breast Cancer Treatment: Nolvadex is used to treat hormone receptor-positive breast cancer in both men and women.
• Breast Cancer Prevention: It is prescribed for reducing the risk of breast cancer in women at high risk of developing the disease.
• Ductal Carcinoma in Situ (DCIS): Nolvadex is used to lower the risk of invasive breast cancer after surgery and radiation therapy for DCIS.
• Infertility Treatment: In certain cases, Nolvadex is used to induce ovulation in women with infertility issues.

Dosage and Administration

• Take Nolvadex exactly as prescribed by your doctor.
• Swallow the tablet whole with a full glass of water.
• Take the tablet at the same time each day to maintain an even level of the drug in your body. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose.
• Do not take more than the recommended dose.
• Avoid skipping doses or stopping the medication without consulting your doctor.
• Do not take Nolvadex if you are pregnant or planning to become pregnant, as it can harm the unborn baby.
• Avoid using other medications or supplements that may interact with Nolvadex without your doctor’s approval.

Mechanism of Action

Nolvadex works by binding to estrogen receptors in breast tissue. By blocking estrogen from binding to these receptors, Nolvadex reduces the growth and proliferation of estrogen-dependent breast cancer cells.

Contraindications

• Do not use Nolvadex if you are allergic to tamoxifen or any other components of the tablet.
• Avoid use if you are pregnant or breastfeeding, as Nolvadex can harm the baby.
• Do not take Nolvadex if you have a history of blood clots or deep vein thrombosis.
• Avoid using it if you have uncontrolled high blood pressure or if you are taking blood thinners like warfarin.

Side Effects

Common Side Effects

• Hot flashes
• Nausea
• Leg cramps
• Muscle aches
• Fatigue
• Mood swings

Serious Side Effects

• Blood clots (e.g., deep vein thrombosis, pulmonary embolism)
• Stroke
• Uterine cancer
• Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, trouble breathing)
• Vision changes

Precautions

• Regularly monitor your blood counts and liver function through blood tests while using Nolvadex.
• Inform your doctor if you have a history of blood clots or other cardiovascular issues.
• Discuss all medications, supplements, and herbal products you are taking with your doctor to avoid interactions.
• Use effective non-hormonal contraception during treatment and for two months after stopping Nolvadex to prevent pregnancy.
• Report any unusual vaginal bleeding, pelvic pain, or changes in menstrual periods to your doctor immediately.

Storage Instructions

• Store Nolvadex tablets at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the medication in its original container, tightly closed, and out of reach of children.
• Protect from light and moisture.
• Do not store it in the bathroom.
• Dispose of any expired or unused medication properly.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/17970s053lbl.pdf