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Naprosyn (naproxen)

Indications

• Naprosyn is prescribed for the relief of mild to moderate pain and inflammation associated with various conditions, such as arthritis, tendinitis, bursitis, and menstrual cramps.
• It is used to manage the symptoms of chronic conditions like osteoarthritis and rheumatoid arthritis, reducing pain and improving joint function.

Dosage and Administration

• Take Naprosyn with food or milk to reduce the risk of stomach upset.
• Take Naprosyn exactly as directed by your healthcare provider, usually 2 to 3 times daily.
• Use the smallest effective dose for the shortest duration possible to minimize the risk of side effects.
• Drink plenty of fluids while taking Naprosyn to help maintain kidney function.
• Avoid taking more than the prescribed amount, as this increases the risk of serious side effects.
• Avoid alcohol as it can increase the risk of stomach bleeding.
• Do Not Skip Doses; consistently take Naprosyn as prescribed to maintain its effectiveness.

Mechanism of Action

Naprosyn (naproxen) is a nonsteroidal anti-inflammatory drug (NSAID). It works by inhibiting the enzymes COX-1 and COX-2, which play a role in the production of prostaglandins. Prostaglandins are chemicals in the body that cause inflammation, pain, and fever. By reducing their production, Naprosyn helps to alleviate these symptoms.

Contraindications

• Known Hypersensitivity to Naproxen: Do not take Naprosyn if you have a known allergy to Naproxen or any of its components.
• History of Asthma or Allergic Reactions to NSAIDs: Avoid Naprosyn if you have had asthma, urticaria, or allergic reactions to aspirin or other NSAIDs.
• Active Gastrointestinal Bleeding or Ulcers: Patients with active gastrointestinal bleeding or ulcers should not use Naprosyn, as it can exacerbate these conditions.
• Severe Kidney or Liver Disease: Patients with severe kidney or liver disease should avoid using Naprosyn.

Side Effects

Common Side Effects:

• Nausea
• Heartburn
• Stomach pain
• Headache
• Dizziness

Serious Side Effects:

• Severe stomach pain or bloody stools
• Vomiting that looks like coffee grounds
• Unexplained weight gain or swelling
• Signs of kidney problems (change in the amount of urine)
• Symptoms of a serious allergic reaction (rash, itching/swelling, severe dizziness, difficulty breathing)

Precautions

• Inform About All Medications: Provide your doctor with a complete list of your current medications to avoid harmful interactions.
• Avoid Use in Late Pregnancy: Naprosyn should not be used in the third trimester of pregnancy due to the risk of harm to the unborn baby.
• Caution if You Have Cardiovascular Disease: Discuss with your doctor if you have a history of heart disease, as Naprosyn can increase the risk of heart attack or stroke.

Storage Instructions

• Keep Naprosyn tablets at 68°F to 77°F (20°C to 25°C).
• Store in the original container to protect from moisture and light.
• Ensure that Naprosyn is stored in a safe place away from children to prevent accidental ingestion.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017581s113,018164s063,020067s020lbl.pdf