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Myfortic (mycophenolic acid)

Indications

• Myfortic tablets are indicated for the prevention of organ rejection in patients receiving kidney transplants.
• Used in combination with other immunosuppressants, such as cyclosporine and corticosteroids, to enhance its effectiveness.
• It helps to reduce the immune response that can lead to transplant rejection.

Dosage and Administration

• Take Myfortic tablets exactly as prescribed by your doctor, usually twice daily.
• Swallow the tablets whole with a full glass of water.
• Take Myfortic on an empty stomach, either 1 hour before or 2 hours after meals, to enhance absorption.
• Maintain a consistent schedule to ensure the best therapeutic effect and avoid missed doses.
• Do not crush, chew, or split the tablets.
• Do not exceed the prescribed dose of Myfortic or take it more frequently than directed by your doctor.
• Avoid taking Myfortic with antacids containing magnesium or aluminum, as they can reduce the absorption of the medication.
• Do not stop taking Myfortic abruptly without consulting your doctor, as it may increase the risk of transplant rejection.

Mechanism of Action

Myfortic contains Mycophenolic acid, an immunosuppressant. It works by inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for the proliferation of T and B lymphocytes. This inhibition reduces the immune system’s ability to mount a response against the transplanted organ, thereby preventing rejection.

Contraindications

• Do not use Myfortic if you have a known allergy to Mycophenolic acid, mycophenolate mofetil, or any other ingredients in the tablets.
• Avoid Myfortic if you are pregnant or planning to become pregnant, as it can cause birth defects and miscarriage.
• Consult your doctor before using the medication if you have existing medical conditions, particularly gastrointestinal disorders, infections, or a history of malignancies.

Side Effects

Common Side Effects:

• Diarrhea
• Nausea
• Vomiting
• Stomach pain
• Headache
• High blood pressure
• Increased susceptibility to infections

Serious Side Effects:

• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Blood disorders (unusual bleeding or bruising, pale skin, fatigue)
• Signs of infection (fever, chills, sore throat, cough)
• Liver problems (yellowing of the skin or eyes, dark urine, severe fatigue)
• Kidney problems (changes in urine output, swelling in the legs or ankles)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Myfortic.
• Be cautious if you have a history of gastrointestinal disorders, as Myfortic can cause stomach-related side effects.
• Monitor for signs of infection and report these symptoms to your doctor immediately, as Myfortic can weaken the immune system.
• Use effective contraception during treatment and for at least 6 weeks after stopping Myfortic to prevent pregnancy.
• Avoid live vaccines while taking Myfortic, as they may not work as well or could cause infections.

Storage Instructions

• Store Myfortic tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original packaging until they are ready to use.
• Do not use Myfortic if the tablets appear discolored, damaged, or show signs of deterioration.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050791s007lbl.pdf