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Mepron (atovaquone)

Indications

• Pneumocystis Pneumonia (PCP): You can use Mepron suspension to treat mild to moderate Pneumocystis pneumonia, a serious lung infection, particularly if you have weakened immune systems, such as from HIV/AIDS.
• Pneumocystis Pneumonia (PCP) Prophylaxis: Your doctor may prescribe Mepron suspension to prevent Pneumocystis pneumonia, especially if you are at high risk due to conditions like HIV/AIDS or other immune deficiencies.

Dosage and Administration

• Shake the bottle well before each use to ensure the suspension is evenly mixed.
• Take Mepron suspension with food to enhance absorption and effectiveness.
• Measure your dose carefully using the provided measuring device or a proper dose-measuring spoon.
• Follow your doctor’s dosing schedule precisely, usually taking it twice daily.
• Inform your doctor about any other medications or supplements you are taking.
• Do not skip doses; take it as soon as you remember if you miss a dose, but do not double dose to make up for a missed one.
• Avoid consuming alcohol while taking Mepron, as it can interfere with the effectiveness and increase side effects.
• Do not mix Mepron suspension with other liquids or foods unless your doctor advises.
• Do not stop taking Mepron without consulting your doctor, even if you feel better.
• Avoid taking antacids within 1 hour before or 2 hours after taking Mepron.

Mechanism of Action

Mepron works by inhibiting the mitochondrial electron transport chain in Pneumocystis jirovecii, the organism responsible for Pneumocystis pneumonia. This action disrupts the energy production within the organism, leading to its death and helping to clear the infection.

Contraindications

• Do not use Mepron if you are allergic to atovaquone or any of its ingredients.
• Avoid using this medication if you have severe liver disease without consulting your doctor.
• Inform your doctor if you are pregnant or planning to become pregnant before starting Mepron.
• Do not use Mepron if you are breastfeeding unless your doctor advises it.

Side Effects

Common Side Effects

• Nausea
• Vomiting
• Diarrhea
• Headache
• Stomach pain

Serious Side Effects

• Severe abdominal pain or persistent nausea/vomiting
• Yellowing of the skin or eyes (jaundice)
• Unusual bleeding or bruising
• Signs of infection (fever, sore throat)
• Severe rash or itching

Precautions

• Inform your doctor about any existing health conditions, especially liver problems or gastrointestinal disorders.
• Regularly monitor your liver function through blood tests as directed by your doctor.
• Use effective contraception during treatment if you are of childbearing age, and consult your doctor if you are pregnant or planning to become pregnant.
• Discuss all other medications you are taking with your doctor to avoid potential interactions.
• Maintain good hydration, especially if you experience vomiting or diarrhea, to prevent dehydration.
• If you experience symptoms of severe side effects, contact your doctor immediately.

Storage Instructions

• Store Mepron suspension at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the bottle tightly closed when not in use.
• Protect from light and moisture.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the label.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020500s017lbl.pdf