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Lodine (etodolac)

Indications

• Lodine is used to relieve the pain and inflammation associated with osteoarthritis, a condition where the protective cartilage in the joints wears down.
• It is prescribed to treat the symptoms of rheumatoid arthritis, an autoimmune disorder that causes chronic inflammation of the joints.
• Lodine is also indicated for the management of mild to moderate acute pain from various conditions, such as injuries or dental procedures.

Dosage and Administration

• Take Lodine exactly as prescribed by your healthcare provider.
• Take the medication with or without food but taking it with food or milk can help prevent stomach upset.
• Take the capsule whole; do not crush, chew, or break it.
• Take the medication at the same time each day for consistent pain relief.
• Do not take more than the prescribed dose, as it can increase the risk of serious side effects.
• Do not consume alcohol while taking Lodine, as it can increase the risk of stomach bleeding.
• Avoid using other NSAIDs (e.g., ibuprofen, aspirin) concurrently without consulting your doctor, as this can increase the risk of side effects.

Mechanism of Action

Lodine (etodolac) is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, substances in the body that cause inflammation, pain, and fever. By blocking the enzyme cyclooxygenase (COX), Lodine reduces the levels of prostaglandins, thereby decreasing inflammation and pain.

Contraindications

• Allergy to Etodolac: Do not use if you have a known allergy to Etodolac or any other ingredients in the capsule.
• Active Peptic Ulcer Disease: Should not be used by patients with active stomach or intestinal ulcers.
• Severe Kidney or Liver Disease: Avoid in patients with severe kidney or liver impairment.
• Heart Surgery: Not recommended for pain management in the setting of coronary artery bypass graft (CABG) surgery.
• Pregnancy: Contraindicated in the third trimester of pregnancy due to the risk of harm to the unborn baby.

Side Effects

Common Side Effects:

• Stomach pain
• Indigestion
• Nausea
• Diarrhea
• Dizziness
• Headache

Serious Side Effects:

• Severe stomach pain or bloody stools (indicative of stomach bleeding)
• Swelling or rapid weight gain
• Liver problems (jaundice, severe fatigue)
• Kidney problems (reduced urine output, swelling in legs or ankles)
• Severe skin reactions (rash, blistering, peeling)
• Allergic reactions (hives, difficulty breathing, swelling of face or throat)

Precautions

• Monitor Gastrointestinal Symptoms: Report any symptoms of stomach bleeding (such as black, tarry stools or vomiting blood) to your doctor immediately.
• Cardiovascular Risk: Be aware that Lodine can increase the risk of serious cardiovascular events like heart attack or stroke, especially with long-term use.
• Liver and Kidney Monitoring: Regular liver and kidney function tests may be required to monitor for potential damage.
• Inform About Other Medications: Tell your doctor about all other medications you are taking to avoid potential interactions.

Storage Instructions

• Store Lodine at room temperature between 20°C to 25°C (68°F to 77°F).
• Store in a dry place, away from moisture and light.
• Keep the capsules in their original container until ready to use.
• Ensure the medication is stored safely away from children.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/018922s022,020584s009lbl.pdf