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Lamisil (terbinafine)

Indications

Lamisil is prescribed for:

• Onychomycosis: Treatment of fungal infections of the toenails and fingernails caused by dermatophytes.
• Tinea Infections: Treatment of various tinea infections, including tinea corporis (ringworm), tinea cruris (jock itch), and tinea pedis (athlete’s foot).
• Other Fungal Infections: Treatment of certain types of yeast infections of the skin.

Dosage and Administration

• Take Lamisil tablets exactly as prescribed by your healthcare provider, typically one 250 mg tablet once daily.
• Continue taking the medication for the entire duration prescribed, usually 6 to 12 weeks for nail infections.
• Take Lamisil with or without food.
• Take the tablet at the same time each day to maintain an even level of medication in your body.
• Stay well-hydrated to help the medication work effectively.
• Do not crush, chew, or break the tablet.
• Do not skip doses; if you miss a dose, take it as soon as you remember unless it is close to the time for your next dose.
• Do not take a double dose to make up for a missed one.

Mechanism of Action

Lamisil works by inhibiting an enzyme called squalene epoxidase in fungal cells. This inhibition leads to a deficiency in ergosterol, a key component of the fungal cell membrane, and an accumulation of squalene, which is toxic to the fungus. This dual action causes the fungal cells to die, effectively treating the infection.

Contraindications

Lamisil should not be used if you:

• Have a Known Hypersensitivity
• Have Severe Liver Problems
• Have Chronic or Active Kidney Problems

Side Effects

Common Side Effects:

• Headache
• Diarrhea
• Indigestion
• Nausea
• Abdominal pain
• Rash

Serious Side Effects:

• Liver problems (symptoms: yellowing of the skin or eyes, dark urine, persistent nausea or vomiting, severe stomach pain)
• Severe skin reactions (symptoms: rash, blistering, peeling)
• Changes in taste or loss of taste
• Mood changes (depression, anxiety)
• Severe allergic reactions (symptoms: rash, itching, swelling, severe dizziness, trouble breathing)
• Blood disorders (symptoms: unusual bleeding or bruising, persistent sore throat or fever)

Precautions

• Monitor Liver Function: Regular liver function tests are necessary to detect early signs of liver damage.
• Monitor for Skin Reactions: Discontinue use and seek medical advice if severe skin reactions occur.
• Inform Your Doctor About Other Medications: Some drugs can interact with Lamisil and affect its efficacy or increase side effects.
• Report Changes in Taste: Notify your healthcare provider if you experience changes in taste or loss of taste.
• Avoid Sun Exposure: Terbinafine can make your skin more sensitive to sunlight; use sunscreen and protective clothing.
• Use Caution in Patients with Psoriasis or Lupus: Terbinafine may exacerbate these conditions.

Storage Instructions

• Keep between 68°F to 77°F (20°C to 25°C).
• Store in a dry place away from direct heat sources.
• Ensure that children do not have access to medication.
• Keep the tablets in the original packaging with the lid tightly closed.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020539s029,022071s013lbl.pdf