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Gleevec (imatinib)

Indications

• Chronic Myeloid Leukemia (CML): Used to treat various phases of CML in adults and children.
• Acute Lymphoblastic Leukemia (ALL): Effective in treating Philadelphia chromosome-positive ALL.
• Gastrointestinal Stromal Tumors (GIST): Treats certain types of stomach or intestinal tumors.
• Dermatofibrosarcoma Protuberans (DFSP): Used to treat this rare type of skin cancer.
• Myelodysplastic/Myeloproliferative Diseases (MDS/MPD): Treats diseases involving abnormal bone marrow cells.

Dosage and Administration

• Take Gleevec with a meal and a large glass of water to reduce stomach irritation.
• Stick to the dosage prescribed by your doctor without alterations.
• Take the medicine at the same time each day for the best effect.
• Swallow the tablets whole.
• Do not miss doses; if you miss one, take it as soon as you remember unless it is close to the next dose.
• Avoid taking a double dose to make up for a missed one.
• Do not consume grapefruit or grapefruit juice while taking Gleevec, as it can affect the medicine’s effectiveness.
• Do not stop taking Gleevec suddenly without consulting your doctor.

Mechanism of Action

Gleevec works by inhibiting the activity of specific proteins (tyrosine kinases) that promote the growth of cancer cells. By blocking these proteins, Gleevec helps to stop or slow the spread of cancer cells.

Contraindications

• Allergy to Imatinib: Do not use it if you have a known allergy to imatinib or any ingredients in the tablets.
• Liver Problems: Not recommended for patients with severe liver disease.
• Other Medications: Avoid using medications that can interact with Imatinib and cause severe side effects.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Muscle cramps
• Fatigue
• Edema (swelling)

Serious Side Effects:

• Severe liver problems (yellowing of skin or eyes, dark urine)
• Severe fluid retention (rapid weight gain, shortness of breath)
• Heart problems (irregular heartbeats, chest pain)
• Severe skin reactions (rash, blistering)
• Bleeding or bruising easily
• Signs of infection (fever, chills, sore throat)

Precautions

• Medical History: Inform your doctor about your full medical history, especially liver, kidney, or heart problems.
• Pregnancy and Breastfeeding: Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Regular Monitoring: Regular blood tests are necessary to monitor your response to the treatment and detect any side effects early.
• Hydration: Drink plenty of fluids to stay hydrated, especially if you experience vomiting or diarrhea.
• Avoid Infections: Be cautious to avoid infections and contact your doctor immediately if you show signs of infection.

Storage Instructions

• Store Gleevec tablets at room temperature, between 59°F to 86°F (15°C to 30°C).
• Protect from moisture, avoid storing it in the bathroom.
• Ensure the medication is kept out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021588s009lbl.pdf