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Deplin (l-methylfolate calcium) 

Indications 

Deplin is used for: 

• Managing depression in adults with low levels of folate in their blood. 
• Supplementing dietary folate for those with certain medical conditions that require additional folate. 

Dosage and Administration 

• Take Deplin exactly as prescribed by your healthcare provider. 
• Swallow the capsule whole with water. 
• Follow the dosage instructions provided by your doctor. 
• Inform your doctor about any other medications you are taking. 
• Do not crush or chew the capsule. 
• Do not change the dosage without consulting your doctor. 
• Avoid taking Deplin if you have a known hypersensitivity to any of its components. 

Mechanism of Action 

Deplin contains L-methylfolate, which is the active form of folate. It helps regulate mood by supporting the production of neurotransmitters like serotonin, norepinephrine, and dopamine in the brain. This can improve symptoms of depression in individuals with low folate levels. 

Contraindications 

Do not use Deplin if you have known hypersensitivity to any of its components. 

Side Effects 

Common Side Effects: 

• Nausea 
• Headache 
• Upset stomach 
• Trouble sleeping 

Serious Side Effects: 

• Allergic reactions (rare) 
• Worsening of depression symptoms (monitor closely) 

Precautions 

• Different from folic acid, Deplin contains L-methylfolate calcium, which is not interchangeable with folic acid. You should be aware that some individuals, possibly including yourself, may not respond well to folic acid due to its limited ability to cross the blood-brain barrier and convert into a biologically active form. 
• If you are at risk for vitamin B12 deficiency, you should consult your medical provider before taking Deplin.  
• You should be monitored for any signs of worsening depression or suicidal thoughts, especially when starting Deplin or adjusting the dosage. Close supervision by your healthcare provider is essential if you have depression or mood disorders. 

Storage Instructions 

• Store Deplin capsules at controlled room temperature, 20 to 25°C (68 to 77°F). 
• Keep away from excessive heat or light. 

References 

https://www.deplin.com/pdf/Deplin-Clear-with-Algal-powder-PI.pdf